Wang Tianzi, Lin Yan, Mao Lingyu, Yu Xueping, Wang Zhenzhen, Liu Huaxu, Zhang Furen
Hospital for Skin Diseases, Shandong First Medical University, Jinan, China.
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China.
Lasers Med Sci. 2025 Jan 30;40(1):54. doi: 10.1007/s10103-025-04296-z.
To investigate the efficacy and safety of picosecond (PS) and nanosecond (NS) 1064-nm neodymium-doped yttrium aluminum garnet (Nd: YAG) laser in treating Café-au-lait macules (CALMs). We retrospectively analyzed the medical records of patients with CALMs, who were treated with PS or NS 1064-nm lasers from January 2020 to January 2022. The efficacy was determined based on the before and after pictures by two independent investigators. The incidence of adverse events and recurrence were explored after treatments. A total of 116 patients (83 in the PS group and 33 in the NS group) were recruited. For subjects in the PS group, after 1-9 sessions, the lesion clearance was poor in 15 patients (18.1%), fair in 29 (34.9%), good in 14 (16.9%), and excellent in 25 (30.1%). In the NS group, after 1-7 sessions, the lesion clearance was poor, fair, good, and excellent in 7 (21.2%), 8 (24.2%), 13 (39.4%), and 5 (15.2%) patients, respectively. There was no statistically significant difference in efficacy between the two lasers (p > 0.05). The incidence of complications (hyperpigmentation, hypopigmentation) in the PS group (16.9%) was numerically lower than in the NS group (24.2%) (p = 0.136). Among patients who responded well to the treatment, 10.3% of patients in the PS group experienced relapse, compared with 22.2% in the NS group (p = 0.926). The PS 1064-nm laser provided comparable efficacy and potentially fewer complications compared with the NS laser in treating CALMs.
为研究皮秒（PS）和纳秒（NS）1064纳米掺钕钇铝石榴石（Nd:YAG）激光治疗咖啡斑（CALMs）的疗效和安全性。我们回顾性分析了2020年1月至2022年1月期间接受PS或NS 1064纳米激光治疗的CALMs患者的病历。由两名独立研究人员根据治疗前后的照片确定疗效。治疗后探讨不良事件和复发的发生率。共招募了116例患者（PS组83例，NS组33例）。PS组患者经1 - 9次治疗后，15例（18.1%）皮损清除较差，29例（34.9%）中等，14例（16.9%）良好，25例（30.1%）优秀。NS组患者经1 - 7次治疗后，皮损清除较差、中等、良好和优秀的分别有7例（21.2%）、8例（24.2%）、13例（39.4%）和5例（15.2%）。两种激光在疗效上无统计学显著差异（p＞0.05）。PS组并发症（色素沉着、色素减退）的发生率（16.9%）在数值上低于NS组（24.2%）（p = 0.136）。在治疗反应良好的患者中，PS组有10.3%的患者复发，而NS组为22.2%（p = 0.926）。在治疗CALMs方面，1064纳米PS激光与NS激光疗效相当，且潜在并发症可能更少。
