International Agency for Research on Cancer , Section of Nutrition and Metabolism, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France.
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford , Richard Doll Building, Oxford OX3 7LF, United Kingdom.
J Proteome Res. 2017 Sep 1;16(9):3137-3146. doi: 10.1021/acs.jproteome.6b01062. Epub 2017 Aug 11.
Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
代谢组学目前广泛用于描述与生活方式风险因素（如肥胖）相关的代谢表型。本研究的目的是探索体重指数（BMI）与欧洲癌症前瞻性调查和营养研究（EPIC）中血液样本中测量的 145 种代谢物之间的关联。在牛津（英国）队列（EPIC-Oxford）的 392 名男性和作为肝胆癌嵌套病例对照研究（EPIC-Hepatobiliary）一部分的 327 名对照者的血液中测量了代谢物。测量的代谢物包括氨基酸、酰基肉碱、己糖、生物胺、磷脂酰胆碱和神经鞘磷脂。运行线性回归模型控制潜在混杂因素和多重检验，以评估代谢物浓度与 BMI 的关联。在 EPIC-Oxford 和 EPIC-Hepatobiliary 亚队列中，分别有 40 和 45 种个体代谢物根据 BMI 变化显示出显著差异。在两个亚队列中，有 22 种个体代谢物（犬尿氨酸、一种神经鞘磷脂、谷氨酸和 19 种磷脂酰胆碱）与 BMI 相关。本研究结果为欧洲成年人 BMI 的血液代谢特征提供了更多的知识，这可能有助于确定介导 BMI 与肥胖相关疾病关系的机制。
