三七蒸制根中的新三萜皂苷。
New triterpenoid saponins from the steaming treated roots of Panax notoginseng.
作者信息
Gu Cheng-Zhen, Qiao Yi-Jun, Wang Dong, Zhu Hong-Tao, Yang Chong-Ren, Xu Min, Zhang Ying-Jun
机构信息
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , People's Republic of China.
c College of Life Science , Fujian Agriculture and Forestry University , Fuzhou , People's Republic of China.
出版信息
Nat Prod Res. 2018 Feb;32(3):294-301. doi: 10.1080/14786419.2017.1356833. Epub 2017 Jul 31.
Further phytochemical investigation of the steaming treated roots of Panax notoginseng (Araliaceae) led to the identification of two new dammarane-type triterpenoid saponins, notoginsenoside SP20 (1) and SP21 (2). In addition, a pair of new phenolic glycosides (3a and 3b) was also isolated together with two known compounds. Their structures were elucidated by HRESIMS, 1D- and 2D-NMR spectra. Compounds 1 and 2 showed no in vitro cytotoxicity against five human cancer cell lines (HL-60, SMMC-7712, A-549, MCF-9 and SW480).
对三七（五加科）蒸制处理后的根进行进一步的植物化学研究，鉴定出两种新的达玛烷型三萜皂苷，三七皂苷SP20（1）和SP21（2）。此外，还分离出一对新的酚苷（3a和3b）以及两种已知化合物。通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振谱（1D-和2D-NMR）对它们的结构进行了阐明。化合物1和2对五种人类癌细胞系（HL-60、SMMC-7712、A-549、MCF-9和SW480）没有体外细胞毒性。
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