School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Nat Prod Res. 2020 Dec;34(24):3462-3469. doi: 10.1080/14786419.2019.1578765. Epub 2019 Feb 27.
Two new triterpenoid saponins, tomentoside T () and tomentoside T (), together with eleven known compounds () were obtained from ethyl acetate extracts of (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines. Compounds and showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC values of 3.73-4.21 μM and 3.53-5.37 μM, respectively.
从（Maxim.）Pei 的乙酸乙酯提取物中，通过生物活性导向分离，得到了两种新的三萜皂苷，绒毛苷 T（）和绒毛苷 T（），以及十一种已知化合物（）。通过化学和光谱分析，包括 1D、2D NMR 数据和 HRESIMS，确定了它们的结构。所有分离出的皂苷的细胞毒性活性均在 MDA-MB-231 和 PC-3 细胞系上进行了评估。化合物和对 MDA-MB-231 细胞和 PC-3 细胞具有显著的细胞毒性，IC 值分别为 3.73-4.21 μM 和 3.53-5.37 μM。
