三七药用真菌物质中的三种新三萜皂苷。

Three New Triterpenoid Saponins from Notoginseng Medicinal Fungal Substance.

作者信息

Xu Wei, Yan Qing-Xia, Liu Ying-Ying, Chang Bai-Jin, Liu Xin, Qiu Zhi-Dong

机构信息

College of Pharmacy, Changchun University of Chinese Medicine, Boshuo Road 1035, Jingyue District, Changchun, 130117, P. R. China.

出版信息

Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700195. Epub 2017 Dec 1.

DOI:10.1002/cbdv.201700195

PMID:28944607

Abstract

Three new triterpenoid saponins, named ginsenoside-Rh (1), ginsenoside-Rh (2), and ginsenoside-Rh (3), were isolated from notoginseng medicinal fungal substance. Their structures were elucidated by a combination of 1D- and 2D-NMR, MS and chemical analysis. Compounds 1 - 3 exhibited moderate cytotoxic activity against MCF-7 and NCI-H460 cancer cell lines.

摘要

从三七药用真菌物质中分离出三种新的三萜皂苷，分别命名为人参皂苷-Rh（1）、人参皂苷-Rh（2）和人参皂苷-Rh（3）。通过一维和二维核磁共振、质谱和化学分析相结合的方法阐明了它们的结构。化合物1-3对MCF-7和NCI-H460癌细胞系表现出中等程度的细胞毒性活性。