三七叶中的达玛烷型皂苷及其对受损SH-SY5Y细胞的神经保护作用。
Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.
作者信息
Liu Xin-Yi, Wang Shan, Li Chuang-Jun, Ma Jie, Chen Fang-You, Peng Ying, Wang Xiao-Liang, Zhang Dong-Ming
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Phytochemistry. 2018 Jan;145:10-17. doi: 10.1016/j.phytochem.2017.09.020. Epub 2017 Oct 14.
Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV, IR, ect.), HR-ESI-MS techniques and chemical methods. Screening results indicated that compounds 4, 5, 12, 13 showed moderate neuroprotective effects on HO-induced cellular damage in human neuroblastoma SH-SY5Y cells (10 μM).
从三七（五加科）的水提叶中分离出7种以前未描述过的达玛烷型皂苷（三七皂苷Fh1 - Fh7）以及11种已知皂苷。通过光谱分析（核磁共振、紫外、红外等）、高分辨电喷雾电离质谱技术和化学方法阐明了它们的结构。筛选结果表明，化合物4、5、12、13对人神经母细胞瘤SH - SY5Y细胞中HO诱导的细胞损伤具有中等程度的神经保护作用（10μM）。
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