朱砂根根部的细胞毒性三萜皂苷

Cytotoxic triterpenoid saponins from the roots of Ardisia crenata.

作者信息

Zheng Zhong-Fei, Xu Jian-Fu, Feng Zi-Ming, Zhang Pei-Cheng

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing, China.

出版信息

J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):833-9. doi: 10.1080/10286020802102568.

DOI:10.1080/10286020802102568

PMID:18985494

Abstract

Ardisiacrenoside I (1), a new triterpenoid pentasaccharide with an unusual glycosyl glycerol side chain, was isolated from Ardisia crenata together with five closely related triterpenoid saponins. Their structures were elucidated by a combination of mass spectrometry, IR, 1D, and 2D NMR spectroscopy. Their cytotoxic activities were evaluated against several different human tumor cell lines by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) method.

摘要

从朱砂根中分离得到了一种新的具有不寻常糖基甘油侧链的三萜五糖——紫金牛苷I（1），以及五种密切相关的三萜皂苷。通过质谱、红外光谱、一维和二维核磁共振光谱相结合的方法阐明了它们的结构。采用3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四氮唑溴盐（MTT）法对几种不同的人类肿瘤细胞系评估了它们的细胞毒性活性。