Herbein Georges
Department Pathogens & Inflammation-EPILAB EA4266, University of Franche-Comté (UFC), 25000 Besançon, France.
Department of Virology, CHU Besançon, 25000 Besançon, France.
Cancers (Basel). 2024 May 22;16(11):1970. doi: 10.3390/cancers16111970.
Epstein-Barr virus (EBV), Kaposi sarcoma human virus (KSHV), human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), human T-lymphotropic virus-1 (HTLV-1), and Merkel cell polyomavirus (MCPyV) are the seven human oncoviruses reported so far. While traditionally viewed as a benign virus causing mild symptoms in healthy individuals, human cytomegalovirus (HCMV) has been recently implicated in the pathogenesis of various cancers, spanning a wide range of tissue types and malignancies. This perspective article defines the biological criteria that characterize the oncogenic role of HCMV and based on new findings underlines a critical role for HCMV in cellular transformation and modeling the tumor microenvironment as already reported for the other human oncoviruses.
爱泼斯坦-巴尔病毒（EBV）、卡波西肉瘤人疱疹病毒（KSHV）、人乳头瘤病毒（HPV）、乙型和丙型肝炎病毒（HBV、HCV）、人类嗜T淋巴细胞病毒1型（HTLV-1）以及默克尔细胞多瘤病毒（MCPyV）是目前已报道的七种人类致癌病毒。虽然传统上认为人类巨细胞病毒（HCMV）是一种在健康个体中引起轻微症状的良性病毒，但最近它被认为与各种癌症的发病机制有关，这些癌症涉及广泛的组织类型和恶性肿瘤。这篇观点文章定义了表征HCMV致癌作用的生物学标准，并基于新发现强调了HCMV在细胞转化以及塑造肿瘤微环境方面的关键作用，这与已报道的其他人类致癌病毒的情况相同。
