Song Guosheng, Shen Jia, Jiang Feiran, Hu Ronggui, Li Wenyao, An Lei, Zou Rujia, Chen Zhigang, Qin Zongyi, Hu Junqing
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201620, China.
ACS Appl Mater Interfaces. 2014 Mar 26;6(6):3915-22. doi: 10.1021/am4050184. Epub 2014 Mar 6.
The molybdenum oxide nanosheets have shown strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. However, the long alky chains of ligands made them hydrophobic and less biocompatible. To meet the requirements of molybdenum based nanomaterials for use as a future photothermal therapy, a simple hydrothermal route has been developed for hydrophilic molybdenum oxide nanospheres and nanoribbons using a molybdenum precursor and poly(ethylene glycol) (PEG). First, molybdenum oxide nanomaterials prepared in the presence of PEG exhibit strong localized surface plasmon resonance (LSPR) absorption in near-infrared (NIR) region, compared with that of no PEG. Second, elevation of synthetic temperature leads to a gradual transformation of molybdenum oxide nanospheres into nanoribbons, entailing the evolution of an intense LSPR absorption in the NIR region. Third, as-prepared molybdenum oxide nanomaterials coated with PEG possess a hydrophilic property and thus can be directly used for biological applications without additional post treatments. Moreover, molybdenum oxide nanoribbons as a model of photothermal materials can efficiently convert the 980 nm wavelength laser energy into heat energy, and this localized hyperthermia produces the effective thermal ablation of cancer cells, meaning a potential photothermal material.
氧化钼纳米片在近红外（NIR）区域表现出强烈的局域表面等离子体共振（LSPR）吸收。然而，配体的长烷基链使其具有疏水性且生物相容性较差。为了满足钼基纳米材料作为未来光热疗法的需求，已开发出一种简单的水热路线，使用钼前驱体和聚乙二醇（PEG）制备亲水性氧化钼纳米球和纳米带。首先，与未添加PEG的情况相比，在PEG存在下制备的氧化钼纳米材料在近红外（NIR）区域表现出强烈的局域表面等离子体共振（LSPR）吸收。其次，合成温度的升高导致氧化钼纳米球逐渐转变为纳米带，这使得在近红外区域的LSPR吸收增强。第三，涂覆有PEG的制备好的氧化钼纳米材料具有亲水性，因此无需额外的后处理即可直接用于生物应用。此外，作为光热材料模型的氧化钼纳米带可以有效地将980nm波长的激光能量转化为热能，这种局部热疗可对癌细胞进行有效的热消融，意味着它是一种潜在的光热材料。
