Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2122-6. doi: 10.1002/anie.201510597. Epub 2015 Dec 28.
Molybdenum oxide (MoOx) nanosheets with high near-infrared (NIR) absorbance and pH-dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx-PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent in vivo toxicity. MoOx-PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx-PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity.
合成了具有高光近红外（NIR）吸收率和 pH 依赖性氧化降解性能的氧化钼（MoOx）纳米片，并用聚乙二醇（PEG）进行功能化，然后用作可降解的光热试剂和药物载体。在酸性 pH 下相对稳定的纳米片可以在生理 pH 下降解。因此，静脉注射后分布在器官中的 MoOx-PEG 会迅速降解并排出体外，而没有明显的体内毒性。MoOx-PEG 在肿瘤中表现出高效的积累，肿瘤的酸性 pH 导致这些纳米片在肿瘤中的滞留时间更长。MoOx-PEG 不仅可以作为光热试剂有效消融肿瘤，还可以高效负载治疗分子。这种无机治疗纳米剂的概念在肿瘤中应该相对稳定，以允许成像和治疗，而在正常器官中容易降解，以实现快速排泄并避免长期滞留/毒性。
