利用全基因组测序首次详细分析表皮葡萄球菌携带的 III 型精氨酸代谢移动元件的结构组织的遗传特征。
First Detailed Genetic Characterization of the Structural Organization of Type III Arginine Catabolic Mobile Elements Harbored by Staphylococcus epidermidis by Using Whole-Genome Sequencing.
机构信息
Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Dublin, Republic of Ireland.
Division of Restorative Dentistry and Periodontology, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Dublin, Republic of Ireland.
出版信息
Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.01216-17. Print 2017 Oct.
The type III arginine catabolic mobile element (ACME) was detected in three oral isolates recovered from separate patients (one healthy, one healthy with dental implants, and one with periodontal disease) based on ACME--operon- and ACME--operon-directed PCR. These isolates were subjected to whole-genome sequencing to characterize the precise structural organization of ACME III for the first time, which also revealed that all three isolates were the same sequence type, ST329.
基于 ACME-操纵子和 ACME-操纵子定向 PCR，从三位不同患者（一位健康，一位健康并植有牙，一位患有牙周病）的口腔分离株中检测到 III 型精氨酸降解移动元件（ACME）。为首次对 ACME III 的精确结构组织进行特征描述，这些分离株进行了全基因组测序，同时也揭示了这三种分离株均为同一序列型，ST329。
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