糖尿病犬的血乳酸浓度
Blood lactate concentration in diabetic dogs.
作者信息
Claus Poliana, Gimenes André M, Castro Jacqueline R, Mantovani Matheus M, Kanayama Khadine K, Simões Denise M N, Schwartz Denise S
机构信息
Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
出版信息
Can Vet J. 2017 Aug;58(8):817-822.
Human diabetic patients may have increased lactate levels compared to non-diabetics. Despite the use of lactate levels in critical care assessment, information is lacking for diabetic dogs. Therefore, this prospective cross-sectional clinical study aimed to determine lactate concentrations in 75 diabetic dogs [25 newly diagnosed non-ketotic diabetics, 25 under insulin treatment, and 25 in diabetic ketoacidosis (DKA)], compared to 25 non-diabetic dogs. Lactate levels (mmol/L) were not different among groups ( = 0.20); median and 25th to 75th percentile were 2.23 and P = 1.46 to 2.83 for controls, 1.69 and P = 1.09 to 2.40 for newly diagnosed non-ketotic diabetics, 2.27 and P = 1.44 to 2.90 for dogs under insulin treatment for at least 30 days, and 2.40 and P = 1.58 to 3.01 for dogs in DKA. Longitudinal studies assessing both isomers (L- and D-lactate) are needed to better elucidate the role of lactate in the pathophysiology of diabetes acid-base status in dogs.
与非糖尿病患者相比，人类糖尿病患者的乳酸水平可能会升高。尽管乳酸水平被用于重症监护评估，但关于糖尿病犬的相关信息却很缺乏。因此，这项前瞻性横断面临床研究旨在测定75只糖尿病犬（25只新诊断的非酮症糖尿病犬、25只接受胰岛素治疗的犬以及25只处于糖尿病酮症酸中毒状态的犬）的乳酸浓度，并与25只非糖尿病犬进行比较。各组间乳酸水平（mmol/L）无差异（ = 0.20）；对照组的中位数及第25至75百分位数分别为2.23和P = 1.46至2.83，新诊断的非酮症糖尿病犬为1.69和P = 1.09至2.40，接受胰岛素治疗至少30天的犬为2.27和P = 1.44至2.90，处于糖尿病酮症酸中毒状态的犬为2.40和P = 1.58至3.01。需要进行评估两种异构体（L-乳酸和D-乳酸）的纵向研究，以更好地阐明乳酸在犬糖尿病酸碱平衡病理生理学中的作用。
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