Aqmasheh Sara, Shamsasanjan Karim, Akbarzadehlaleh Parvin, Pashoutan Sarvar Davod, Timari Hamze
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2017 Jun;7(2):165-177. doi: 10.15171/apb.2017.021. Epub 2017 Jun 30.
Hematopoiesis is a balance among quiescence, self-renewal, proliferation, and differentiation, which is believed to be firmly adjusted through interactions between hematopoietic stem and progenitor cells (HSPCs) with the microenvironment. This microenvironment is derived from a common progenitor of mesenchymal origin and its signals should be capable of regulating the cellular memory of transcriptional situation and lead to an exchange of stem cell genes expression. Mesenchymal stem cells (MSCs) have self-renewal and differentiation capacity into tissues of mesodermal origin, and these cells can support hematopoiesis through release various molecules that play a crucial role in migration, homing, self-renewal, proliferation, and differentiation of HSPCs. Studies on the effects of MSCs on HSPC differentiation can develop modern solutions in the treatment of patients with hematologic disorders for more effective Bone Marrow (BM) transplantation in the near future. However, considerable challenges remain on realization of how paracrine mechanisms of MSCs act on the target tissues, and how to design a therapeutic regimen with various paracrine factors in order to achieve optimal results for tissue conservation and regeneration. The aim of this review is to characterize and consider the related aspects of the ability of MSCs secretome in protection of hematopoiesis.
造血作用是静止、自我更新、增殖和分化之间的一种平衡，人们认为这种平衡是通过造血干细胞和祖细胞（HSPCs）与微环境之间的相互作用来严格调节的。这种微环境源自间充质来源的共同祖细胞，其信号应该能够调节转录状态的细胞记忆，并导致干细胞基因表达的交换。间充质干细胞（MSCs）具有自我更新能力，并能分化为中胚层来源的组织，这些细胞可以通过释放各种分子来支持造血作用，这些分子在HSPCs的迁移、归巢、自我更新、增殖和分化中起着关键作用。对MSCs对HSPC分化影响的研究可以在不久的将来开发出现代解决方案，用于治疗血液系统疾病患者，以实现更有效的骨髓（BM）移植。然而，在了解MSCs的旁分泌机制如何作用于靶组织，以及如何设计含有各种旁分泌因子的治疗方案以实现组织保护和再生的最佳效果方面，仍然存在相当大的挑战。本综述的目的是描述和探讨MSCs分泌组在保护造血作用方面能力的相关问题。
