Grobbee D E, Hofman A
Lancet. 1986 Sep 27;2(8509):703-7. doi: 10.1016/s0140-6736(86)90228-x.
In a double-blind trial 90 mildly hypertensive subjects aged 16-29 years were randomly assigned to 1 g calcium per day or placebo. Calcium supplementation did not affect systolic blood pressure, but at six and twelve weeks diastolic blood pressure had fallen by 3.1 (p = 0.04) and 2.4 (p = 0.11) mm Hg, respectively, more in the calcium group than it had in the placebo group. Subjects with a baseline plasma parathyroid hormone (PTH) higher than the median showed a 6.1 mm Hg (p = 0.01) greater fall in diastolic blood pressure after six weeks and 5.4 mm Hg (p = 0.01) after twelve than in the placebo group. The fall in diastolic blood pressure was greater in the calcium group than in the placebo group in subjects with a lower than median serum total calcium and in those with a large bodyweight. Calcium supplementation may lower blood pressure in young people with mildly raised blood pressure, particularly in those with high plasma PTH and/or low serum total calcium.
在一项双盲试验中，90名年龄在16至29岁的轻度高血压受试者被随机分为两组，一组每天补充1克钙，另一组服用安慰剂。补钙对收缩压没有影响，但在六周和十二周时，补钙组的舒张压分别比安慰剂组下降了3.1（p = 0.04）和2.4（p = 0.11）毫米汞柱。基线血浆甲状旁腺激素（PTH）高于中位数的受试者，六周后舒张压下降幅度比安慰剂组大6.1毫米汞柱（p = 0.01），十二周后大5.4毫米汞柱（p = 0.01）。血清总钙低于中位数的受试者以及体重较大的受试者，补钙组的舒张压下降幅度大于安慰剂组。补钙可能会降低轻度血压升高的年轻人的血压，尤其是血浆PTH高和/或血清总钙低的人。
