Department of Perinatology and Gynecology, Polish Mother's Memorial Hospital Research Institute, ul. Rzgowska 281/289, 93-338, Łódź, Poland.
PreMediCare New Med Medical Centre, ul. Drużbickiego 13, 61-693, Poznań, Poland.
Biol Trace Elem Res. 2018 Apr;182(2):217-223. doi: 10.1007/s12011-017-1109-9. Epub 2017 Aug 1.
The mineral levels in maternal serum change during pregnancy and may be correlated with those of newborn cord blood. The aim of this study was to evaluate the concentrations of calcium (Ca), magnesium (Mg), zinc (Zn), iron (Fe), and copper (Cu) in maternal blood before and after delivery and in umbilical cord vein and artery serum. The study was carried out in 64 Caucasian pregnant women who delivered in a district hospital in Greater Poland region, aged 28.1 ± 5.4 years, with a mean gestational age of 39.2 ± 1.3 weeks. Blood samples were taken from women 2-8 h before delivery and immediately after childbirth. The umbilical cord artery and vein blood of newborns was obtained immediately after childbirth. The levels of minerals in serum were determined by flame atomic absorption spectrometry. A significant drop in the concentrations of Mg (17.71 ± 1.51 vs 17.07 ± 1.61 μg/ml; p < 0.007), Fe (1.08 ± 0.46 vs 0.82 ± 0.35 μg/ml; p < 0.0004), and Zn (0.63 ± 0.17 vs 0.46 ± 0.16; p < 0.0001) in maternal serum was found after delivery. Moreover, higher levels of Ca, Fe, and Zn and lower levels of Cu were observed in the umbilical vein (Ca: 102.80 ± 7.80 μg/ml; p < 0.0001, Fe: 1.96 ± 0.43 μg/ml; p < 0.0001, Zn: 0.65 ± 0.16 μg/ml; p < 0.0001, Cu: 0.36 ± 0.09 μg/ml; p < 0.0001) and in the umbilical artery cord blood (Ca: 98.07 ± 8.18 μg/ml; p < 0.0001, Fe: 1.63 ± 0.30 μg/ml; p < 0.0001, Zn: 0.65 ± 0.15 μg/ml; p < 0.0001, and Cu: 0.36 ± 0.10 μg/ml; p < 0.0001) compared to the maternal serum (Ca: 85.05 ± 10.76 μg/ml, Fe: 0.82 ± 0.35 μg/ml, Zn: 0.46 ± 0.16 μg/ml, and Cu: 1.90 ± 0.35 μg/ml). Fe levels in the cord artery serum negatively correlated with blood loss during delivery (R = -0.48; p = 0.01), while the Ca concentration in the maternal serum after birth decreased with the age of the women (R = -0.25; p = 0.03). In conclusion, it seems that the process of birth alters the mineral levels in pregnant women's blood. Moreover, it was found that blood loss and the age of the mother are associated with mineral concentrations in the maternal serum and cord artery blood.
孕妇血清中的矿物质水平在怀孕期间会发生变化，并且可能与新生儿脐血中的矿物质水平相关。本研究的目的是评估 64 名在大波兰地区一家地区医院分娩的高加索孕妇分娩前后以及脐静脉和脐动脉血清中钙（Ca）、镁（Mg）、锌（Zn）、铁（Fe）和铜（Cu）的浓度。这些孕妇的年龄为 28.1±5.4 岁，平均孕龄为 39.2±1.3 周。在分娩前 2-8 小时和分娩后立即从女性身上采集血液样本。新生儿的脐动脉和脐静脉血在分娩后立即采集。通过火焰原子吸收光谱法测定血清中矿物质的水平。与分娩前相比，产妇血清中 Mg（17.71±1.51 对 17.07±1.61μg/ml；p<0.007）、Fe（1.08±0.46 对 0.82±0.35μg/ml；p<0.0004）和 Zn（0.63±0.17 对 0.46±0.16μg/ml；p<0.0001）的浓度显著下降。此外，在脐静脉（Ca：102.80±7.80μg/ml；p<0.0001，Fe：1.96±0.43μg/ml；p<0.0001，Zn：0.65±0.16μg/ml；p<0.0001，Cu：0.36±0.09μg/ml；p<0.0001）和脐动脉（Ca：98.07±8.18μg/ml；p<0.0001，Fe：1.63±0.30μg/ml；p<0.0001，Zn：0.65±0.15μg/ml；p<0.0001，Cu：0.36±0.10μg/ml；p<0.0001）中 Ca、Fe、Zn 的水平较高，Cu 的水平较低，而与产妇血清（Ca：85.05±10.76μg/ml，Fe：0.82±0.35μg/ml，Zn：0.46±0.16μg/ml，Cu：1.90±0.35μg/ml）相比。脐动脉血清中的 Fe 水平与分娩时的失血量呈负相关（R=-0.48；p=0.01），而产妇产后血清中的 Ca 浓度随孕妇年龄的增加而降低（R=-0.25；p=0.03）。总之，分娩过程似乎会改变孕妇血液中的矿物质水平。此外，还发现失血量和母亲年龄与产妇血清和脐动脉血中的矿物质浓度相关。
Zotero 插件