Gardner W N, Meah M S, Bass C
Lancet. 1986 Oct 11;2(8511):826-30. doi: 10.1016/s0140-6736(86)92867-9.
The respiratory responses of 17 patients with chronic hyperventilation but without demonstrable organic disease (group H) to various manoeuvres were compared with those of 21 healthy controls (group C). The responses were tested according to a 60 min protocol in which periods of rest were replaced by exercise, voluntary hyperventilation (VHV), reading, and CO2 inhalation. 5 patients with severe resting hypocapnia were investigated overnight during sleep. Chronic hyperventilation was of two types--persistent or provoked by exercise or VHV. It was due to modest increases in tidal volume and respiratory frequency but was generally not conspicuous. End-tidal PCO2 levels were gradually corrected to near normal during sleep but not by inhalation of CO2.
将17例慢性通气过度但无明显器质性疾病的患者（H组）对各种操作的呼吸反应与21名健康对照者（C组）的反应进行了比较。根据一个60分钟的方案测试反应，其中休息时段被运动、自主过度通气（VHV）、阅读和吸入二氧化碳所取代。对5例严重静息性低碳酸血症患者进行了夜间睡眠期间的调查。慢性通气过度有两种类型——持续性或由运动或VHV诱发。它是由于潮气量和呼吸频率适度增加所致，但通常不明显。呼气末PCO2水平在睡眠期间逐渐恢复至接近正常，但吸入二氧化碳不能使其恢复正常。
