Thompson R E, Piper D J, Kidd K A
Toxicol Pathol. 1986;14(2):232-7. doi: 10.1177/019262338601400212.
Adenosine deaminase binding protein (AdAbp), a glycoprotein found in the epithelial cells of the brush border of the proximal tubule, is shed into urine following kidney damage. A sandwich enzyme immunoassay is described that uses two monoclonal antibodies, URO-4 (S27) and URO-4a (S23), which react with different epitopes on AdAbp (2, 24). Release of AdAbp into the urine appears to reflect the severity of the insult to the nephron and its measurement may assist in distinguishing between tubular disease and glomerular disease and may be useful in indicating renal toxicity.
腺苷脱氨酶结合蛋白（AdAbp）是一种在近端小管刷状缘上皮细胞中发现的糖蛋白，肾脏受损后会释放入尿液中。本文描述了一种夹心酶免疫测定法，该方法使用两种单克隆抗体URO - 4（S27）和URO - 4a（S23），它们与AdAbp上的不同表位发生反应（2, 24）。AdAbp释放入尿液似乎反映了肾单位受损伤的严重程度，对其进行测量可能有助于区分肾小管疾病和肾小球疾病，并且可能有助于指示肾毒性。
