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组蛋白去乙酰化酶HDAC1表达与肺癌的进展及预后相关：一项荟萃分析。

Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis.

作者信息

Cao Lin-Lin, Song Xiaoxu, Pei Lin, Liu Lianhua, Wang Hui, Jia Mei

机构信息

Department of Clinical Laboratory, Peking University People's Hospital, Beijing Department of Clinical Laboratory, Wu'an First People's Hospital, Handan, China.

出版信息

Medicine (Baltimore). 2017 Aug;96(31):e7663. doi: 10.1097/MD.0000000000007663.

DOI:10.1097/MD.0000000000007663
PMID:28767587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5626141/
Abstract

BACKGROUND

Histone deacetylase 1 (HDAC1) is an important epigenetic factor, and is thought to be associated with the progression and prognosis of some types of cancer. HDAC1 has been reported to be overexpressed in lung cancer, but the correlation between HDAC1 overexpression and the clinical features or prognosis of lung cancer is controversial. In this study, we investigated the potential association between HDAC1 and lung cancer.

MATERIALS AND METHODS

Embase, Web of Science, PubMed, and other sources were searched for relevant studies. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence interval (CI) were calculated to evaluate the association of HDAC1 with lung cancer risk.

RESULTS

Eight eligible studies were included in the final meta-analysis. We found that HDAC1 mRNA or protein expression was closely associated with the differentiation grade of lung cancer (OR = 2.36, 95% CI = 1.14-4.87, P = .02). In addition, the protein expression level of HDAC1 in squamous cell carcinoma was higher than that in adenocarcinoma (OR = 1.81, 95% CI = 1.13-2.90, P = .01). Finally, HDAC1 mRNA or protein expression was negatively correlated with the overall survival rate of patients with lung cancer (HR = 2.40, 95% CI = 1.48-3.88, P = .0004).

CONCLUSION

In this meta-analysis, our results suggest that HDAC1 may serve as a good diagnostic and prognostic marker for lung cancer.

摘要

背景

组蛋白去乙酰化酶1（HDAC1）是一种重要的表观遗传因子，被认为与某些类型癌症的进展和预后相关。据报道，HDAC1在肺癌中过表达，但HDAC1过表达与肺癌临床特征或预后之间的相关性存在争议。在本研究中，我们调查了HDAC1与肺癌之间的潜在关联。

材料与方法

检索Embase、科学网、PubMed及其他来源的相关研究。计算合并比值比（OR）或风险比（HR）及95%置信区间（CI），以评估HDAC1与肺癌风险的关联。

结果

最终的荟萃分析纳入了8项合格研究。我们发现HDAC1 mRNA或蛋白表达与肺癌的分化程度密切相关（OR = 2.36，95% CI = 1.14 - 4.87，P = 0.02）。此外，HDAC1在鳞状细胞癌中的蛋白表达水平高于腺癌（OR = 1.81，95% CI = 1.13 - 2.90，P = 0.01）。最后，HDAC1 mRNA或蛋白表达与肺癌患者的总生存率呈负相关（HR = 2.40，95% CI = 1.48 - 3.88，P = 0.0004）。

结论

在这项荟萃分析中，我们的结果表明HDAC1可能是肺癌的一个良好诊断和预后标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/187d313c0f2f/medi-96-e7663-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/013d0fb53cee/medi-96-e7663-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/38de181636f5/medi-96-e7663-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/187d313c0f2f/medi-96-e7663-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/013d0fb53cee/medi-96-e7663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/a41c304eae68/medi-96-e7663-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/6b5c80876b39/medi-96-e7663-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/0cada3898455/medi-96-e7663-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/38de181636f5/medi-96-e7663-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/c61e55bae089/medi-96-e7663-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/020d/5626141/187d313c0f2f/medi-96-e7663-g008.jpg

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