Crawford P C, Clark W B
Infect Immun. 1986 Nov;54(2):516-21. doi: 10.1128/iai.54.2.516-521.1986.
Experiments were performed to determine whether immunization of mice with fimbrial adhesins isolated from Actinomyces viscosus T14V could modulate infection of tooth surfaces in animals challenged with the homologous strain. Saliva and sera from animals immunized in the submandibular gland region contained elevated levels of fimbria-specific immunoglobulin A (IgA) and IgG, whereas saliva and sera from sham-immunized animals did not. There was a statistically significant inverse correlation between the presence of fimbria-specific antibodies in saliva and serum and the levels of bacterial colonization on molar tooth surfaces. These results suggest that fimbrial adhesins may effectively modulate infection of tooth surfaces by periodontopathic bacteria.
进行实验以确定用从粘性放线菌T14V分离的菌毛粘附素免疫小鼠是否能调节在受到同源菌株攻击的动物中牙齿表面的感染。在颌下腺区域免疫的动物的唾液和血清中，菌毛特异性免疫球蛋白A（IgA）和IgG水平升高，而假免疫动物的唾液和血清中则没有。唾液和血清中菌毛特异性抗体的存在与磨牙表面细菌定植水平之间存在统计学上显著的负相关。这些结果表明，菌毛粘附素可能有效地调节牙周病原菌对牙齿表面的感染。
