• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

姜黄素通过AKT-PTEN-FOXO4信号通路诱导p53基因缺失的肝癌细胞系Hep3B凋亡。

Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.

作者信息

Liou An-Ting, Chen Mei-Fang, Yang Chu-Wen

机构信息

Department of Microbiology, Soochow University, Shihlin, Taipei 111, Taiwan.

Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2017;2017:4063865. doi: 10.1155/2017/4063865. Epub 2017 Jul 9.

DOI:10.1155/2017/4063865
PMID:28769986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5523542/
Abstract

OBJECTIVE

Curcumin (diferuloylmethane) is a yellow-colored polyphenol with antiproliferative and proapoptotic activities to various types of cancer cells. This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis.

RESULTS

AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment. Conversely, PTEN was upregulated. Subcellular fractionations revealed that the FOXO4 protein translocated from cytosol into the nucleus after curcumin treatment. Overexpression of FOXO4 increases the sensitivity of Hep3B cells to curcumin. Knockdown of the FOXO4 gene by siRNA inhibits the proapoptotic effects of curcumin on Hep3B cell.

CONCLUSIONS

This study revealed the AKT/PTEN/FOXO4 pathway as a potential candidate of target for treatment of p53-null liver cancers.

摘要

目的

姜黄素（二阿魏酰甲烷）是一种黄色多酚，对多种癌细胞具有抗增殖和促凋亡活性。本研究探讨了姜黄素诱导p53基因缺失的肝癌细胞凋亡的机制。

结果

姜黄素处理后，AKT、FOXO1和FOXO3蛋白表达下调。相反，PTEN表达上调。亚细胞分级分离显示，姜黄素处理后FOXO4蛋白从细胞质转移到细胞核。FOXO4过表达增加了Hep3B细胞对姜黄素的敏感性。用小干扰RNA敲低FOXO4基因可抑制姜黄素对Hep3B细胞的促凋亡作用。

结论

本研究揭示了AKT/PTEN/FOXO4通路是治疗p53基因缺失肝癌的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/d1b4ad094980/ECAM2017-4063865.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/3552980941d6/ECAM2017-4063865.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/51cc1548d122/ECAM2017-4063865.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/5c45ae787a9d/ECAM2017-4063865.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/4d118d8c27d6/ECAM2017-4063865.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/1b140d5db224/ECAM2017-4063865.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/2af022b034fe/ECAM2017-4063865.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/0431846e354e/ECAM2017-4063865.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/d1b4ad094980/ECAM2017-4063865.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/3552980941d6/ECAM2017-4063865.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/51cc1548d122/ECAM2017-4063865.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/5c45ae787a9d/ECAM2017-4063865.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/4d118d8c27d6/ECAM2017-4063865.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/1b140d5db224/ECAM2017-4063865.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/2af022b034fe/ECAM2017-4063865.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/0431846e354e/ECAM2017-4063865.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e3/5523542/d1b4ad094980/ECAM2017-4063865.008.jpg

相似文献

1
Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.姜黄素通过AKT-PTEN-FOXO4信号通路诱导p53基因缺失的肝癌细胞系Hep3B凋亡。
Evid Based Complement Alternat Med. 2017;2017:4063865. doi: 10.1155/2017/4063865. Epub 2017 Jul 9.
2
Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.Bcl-2家族成员、磷脂酰肌醇3'-激酶/AKT和线粒体p53在姜黄素（二阿魏酰甲烷）诱导前列腺癌细胞凋亡中的作用
Int J Oncol. 2007 Apr;30(4):905-18.
3
Curcumin induces apoptosis in p53-null Hep3B cells through a TAp73/DNp73-dependent pathway.姜黄素通过TAp73/DNp73依赖途径诱导p53基因缺失的Hep3B细胞凋亡。
Tumour Biol. 2016 Mar;37(3):4203-12. doi: 10.1007/s13277-015-4029-3. Epub 2015 Oct 22.
4
Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell.姜黄素的抗癌作用通过miR-21/PTEN/Akt通路抑制乳腺癌细胞的生长。
Oncol Lett. 2017 Jun;13(6):4825-4831. doi: 10.3892/ol.2017.6053. Epub 2017 Apr 20.
5
Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.姜黄素诱导卵巢癌细胞凋亡与 p53 无关，涉及 p38 丝裂原活化蛋白激酶的激活以及下调 Bcl-2 和 survivin 的表达和 Akt 信号通路。
Mol Carcinog. 2010 Jan;49(1):13-24. doi: 10.1002/mc.20571.
6
Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer.姜黄素通过激活非小细胞肺癌中的p53-miR-192-5p/215-XIAP途径促进细胞凋亡。
Cancer Lett. 2015 Feb 1;357(1):196-205. doi: 10.1016/j.canlet.2014.11.028. Epub 2014 Nov 18.
7
Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.姜黄素调节miR-21/PTEN/Akt信号通路，并与PD98059协同作用诱导人胃癌MGC-803细胞凋亡。
J Int Med Res. 2019 Mar;47(3):1288-1297. doi: 10.1177/0300060518822213. Epub 2019 Feb 6.
8
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats.IGF-1/PTEN/Akt/FoxO 信号通路对水浸束缚应激诱导大鼠胃溃疡发生发展及愈合的影响。
Int J Mol Med. 2012 Sep;30(3):650-8. doi: 10.3892/ijmm.2012.1041. Epub 2012 Jun 20.
9
Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway.姜黄素通过诱导叉头框蛋白O1和抑制PI3K/Akt信号通路诱导胰腺癌细胞凋亡。
Mol Med Rep. 2015 Oct;12(4):5415-22. doi: 10.3892/mmr.2015.4060. Epub 2015 Jul 8.
10
[Curcumin induces apoptosis by PTEN/PI3K/AKT pathway in EC109 cells].姜黄素通过PTEN/PI3K/AKT途径诱导EC109细胞凋亡
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Mar;31(2):174-7.

引用本文的文献

1
Anticancer Potential of Indole Phytoalexins and Their Analogues.吲哚植物抗毒素及其类似物的抗癌潜力。
Molecules. 2024 May 19;29(10):2388. doi: 10.3390/molecules29102388.
2
The effect of JQ1 systemic administration on oxidative stress and apoptotic markers in renal ischemic reperfusion injury in a rat model.JQ1 全身给药对大鼠肾缺血再灌注损伤氧化应激和凋亡标志物的影响。
J Med Life. 2023 May;16(5):682-688. doi: 10.25122/jml-2022-0287.
3
Curcumin nanocapsules effect in apoptotic processes, gene expression, and cell cycle on Hep-G2 cell lines.

本文引用的文献

1
Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy.靶向主要细胞信号通路的天然化合物：骨肉瘤治疗的新范例
J Hematol Oncol. 2017 Jan 7;10(1):10. doi: 10.1186/s13045-016-0373-z.
2
Unraveling the Anticancer Effect of Curcumin and Resveratrol.解析姜黄素和白藜芦醇的抗癌作用
Nutrients. 2016 Nov 10;8(11):628. doi: 10.3390/nu8110628.
3
Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway.
姜黄素纳米胶囊对 Hep-G2 细胞系细胞凋亡过程、基因表达和细胞周期的影响。
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231176396. doi: 10.1177/03946320231176396.
4
Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells.姜黄素对高糖诱导的肝癌细胞化疗耐药性的拮抗作用。
Front Oncol. 2021 Oct 6;11:738961. doi: 10.3389/fonc.2021.738961. eCollection 2021.
5
Role of Forkhead Box O Proteins in Hepatocellular Carcinoma Biology and Progression (Review).叉头框O蛋白在肝细胞癌生物学及进展中的作用（综述）
Front Oncol. 2021 May 27;11:667730. doi: 10.3389/fonc.2021.667730. eCollection 2021.
6
Brassinin Inhibits Proliferation in Human Liver Cancer Cells via Mitochondrial Dysfunction.菜豆素通过线粒体功能障碍抑制人肝癌细胞的增殖。
Cells. 2021 Feb 5;10(2):332. doi: 10.3390/cells10020332.
7
Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically.长链非编码RNA MEG3通过表观遗传方式阻断人肝癌干细胞中的端粒酶活性。
Stem Cell Res Ther. 2020 Nov 30;11(1):518. doi: 10.1186/s13287-020-02036-4.
8
Current perspective on the regulation of FOXO4 and its role in disease progression.当前对 FOXO4 调节及其在疾病进展中作用的认识。
Cell Mol Life Sci. 2020 Feb;77(4):651-663. doi: 10.1007/s00018-019-03297-w. Epub 2019 Sep 16.
9
The adipokine vaspin reduces apoptosis in human hepatocellular carcinoma (Hep-3B) cells, associated with lower levels of NO and superoxide anion.脂肪因子 vaspin 可减少人肝癌（Hep-3B）细胞的凋亡，与较低水平的 NO 和超氧阴离子有关。
BMC Pharmacol Toxicol. 2019 Sep 11;20(1):58. doi: 10.1186/s40360-019-0334-6.
10
Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress.Brd4 抑制通过阻断 FoxO4 介导的氧化应激缓解肾缺血/再灌注损伤诱导的细胞凋亡和内质网应激。
Redox Biol. 2019 Jun;24:101195. doi: 10.1016/j.redox.2019.101195. Epub 2019 Apr 11.
姜黄素通过负向调节PI3K/AKT信号通路促进人肾癌细胞的细胞周期阻滞并抑制其存活。
Cell Biochem Biophys. 2015 Dec;73(3):681-6. doi: 10.1007/s12013-015-0694-5.
4
Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence.膳食植物化学物质与癌症化学预防：临床证据综述
Oncotarget. 2016 Aug 9;7(32):52517-52529. doi: 10.18632/oncotarget.9593.
5
Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region.亚太地区肝细胞癌的流行病学
Gut Liver. 2016 May 23;10(3):332-9. doi: 10.5009/gnl15257.
6
Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials.了解膳食植物化学物质预防癌症的分子机制：从实验模型到临床试验。
World J Biol Chem. 2016 Feb 26;7(1):88-99. doi: 10.4331/wjbc.v7.i1.88.
7
Curcumin and Health.姜黄素与健康。
Molecules. 2016 Feb 25;21(3):264. doi: 10.3390/molecules21030264.
8
Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells.姜黄素通过PI3K/Akt信号通路诱导SKOV3细胞凋亡。
Pharm Biol. 2016 Oct;54(10):2026-32. doi: 10.3109/13880209.2016.1139601. Epub 2016 Feb 24.
9
Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation.姜黄素通过自噬依赖性Akt降解抑制MDA-MB-231乳腺癌细胞的增殖和迁移。
PLoS One. 2016 Jan 11;11(1):e0146553. doi: 10.1371/journal.pone.0146553. eCollection 2016.
10
Cancer statistics, 2016.癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.