Miyazaki Noriko, Kobayashi Yoichi, Nishigaya Yoshiko, Momomura Mai, Matsumoto Hironori, Iwashita Mitsutoshi
Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Japan.
J Obstet Gynaecol Res. 2013 Aug;39(8):1363-6. doi: 10.1111/jog.12058. Epub 2013 Jun 26.
We report an extremely rare case of primary ovarian Burkitt lymphoma. A 15-year-old girl was referred to our department because of persistent constipation and abdominal distension. Abdominal computed tomography and magnetic resonance imaging revealed a 10-cm-diameter solid tumor located on the right side of the uterus. Serum lactate dehydrogenase and carbohydrate antigen-125 levels were elevated at 3250 IU/L and 235.7 U/mL, respectively. Initially, ovarian dysgerminoma was suspected, but poor performance and progressive disease were suggestive of malignant lymphoma. However, bone marrow aspiration and ascitic fluid cytology findings were not indicative of lymphoma. Laparotomy was performed to confirm pathology. On laparotomy, the right ovary was firm and enlarged, but the uterus and left ovary were normal. Diffuse thickness of retroperitoneal space was observed. Right salpingo-oophorectomy was performed, and the tumor was diagnosed as Burkitt lymphoma. Although intensive chemotherapy was administered, the patient died 171 days after the initial operation.
我们报告一例极其罕见的原发性卵巢伯基特淋巴瘤病例。一名15岁女孩因持续便秘和腹胀转诊至我科。腹部计算机断层扫描和磁共振成像显示子宫右侧有一个直径10厘米的实性肿瘤。血清乳酸脱氢酶和糖类抗原125水平分别升高至3250 IU/L和235.7 U/mL。最初怀疑为卵巢无性细胞瘤,但表现不佳和病情进展提示为恶性淋巴瘤。然而,骨髓穿刺和腹水细胞学检查结果并不提示淋巴瘤。进行剖腹手术以确诊病理。剖腹手术时,右侧卵巢质地坚硬且增大,但子宫和左侧卵巢正常。观察到腹膜后间隙弥漫性增厚。实施了右侧输卵管卵巢切除术,肿瘤被诊断为伯基特淋巴瘤。尽管给予了强化化疗,但患者在初次手术后171天死亡。