Chen Guobao, Lv Yonggang
Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, People's Republic of China.
Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, 174 Shazheng Street, Shapingba District, Chongqing, 400044, People's Republic of China.
Methods Mol Biol. 2018;1577:239-254. doi: 10.1007/7651_2017_50.
Decellularized bone matrix is gaining a lot of attention as implantable biomaterials and/or biological scaffolds for bone tissue repair, and shows good clinical performance. This chapter describes the processing techniques and characterization protocols of decellularized bone. For the applications of the decellularized bone scaffold in promoting bone repair and regeneration, we discuss some of the current advances, and highlight the advantages and disadvantages of these scaffolds. Fabrication and application of the hydrogel derived from decellularized bone for bone tissue engineering are also presented.
脱细胞骨基质作为用于骨组织修复的可植入生物材料和/或生物支架正受到广泛关注,并显示出良好的临床性能。本章描述了脱细胞骨的处理技术和表征方案。对于脱细胞骨支架在促进骨修复和再生中的应用,我们讨论了一些当前的进展,并强调了这些支架的优缺点。还介绍了源自脱细胞骨的水凝胶在骨组织工程中的制备和应用。