Witteman J C, Kok F J, van Saase J L, Valkenburg H A
Lancet. 1986 Nov 15;2(8516):1120-2. doi: 10.1016/s0140-6736(86)90530-1.
Since aortic calcification is seen on X-rays of the prelumbar region in many patients, its relation with cardiovascular disease (CVD) was investigated in a prospective study in The Netherlands. X-rays were taken of 1359 men and 1598 women, in 1975-78. In the subsequent 9 years, 50 men and 33 women died from CVD. The prevalence of aortic calcification was about 10% in middle-aged subjects and rose with age to a maximum of 45% in men and 75% in women. Aortic calcification was associated with a six-fold increased risk of CVD death in men aged 45 years, independent of major CVD risk factors. For each year of age over 45, risk associated with the presence of aortic calcification declined by 6%. Death rates in middle-aged women were too small for risk analysis. These results suggest that atherosclerosis in other than coronary or cerebral vessels may have predictive relevance for CVD death: its diagnosis indicates intervention on present CVD risk factors.
由于许多患者腰椎前区的X线片上可见主动脉钙化，因此在荷兰的一项前瞻性研究中对其与心血管疾病（CVD）的关系进行了调查。1975年至1978年期间，对1359名男性和1598名女性进行了X线检查。在随后的9年中，50名男性和33名女性死于心血管疾病。中年受试者中主动脉钙化的患病率约为10%，并随年龄增长而上升，男性最高可达45%，女性最高可达75%。在45岁的男性中，主动脉钙化与心血管疾病死亡风险增加六倍相关，且独立于主要的心血管疾病风险因素。45岁以上的每增加一岁，主动脉钙化相关的风险下降6%。中年女性的死亡率过低，无法进行风险分析。这些结果表明，冠状动脉或脑血管以外的动脉粥样硬化可能对心血管疾病死亡具有预测意义：其诊断表明应对当前的心血管疾病风险因素进行干预。
