de Bruin Irma J A, Wyers Caroline E, Vranken Lisanne, Schousboe John T, van der Velde Robert Y, Janzing Heinrich M J, Lambers Heerspink Frederik O, Geusens Piet P M M, van den Bergh Joop P
Department of Internal Medicine, VieCuri Medical Centre, P.O. Box 1926, 5900 BX, Venlo, The Netherlands.
Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ (Maastricht UMC+), P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Osteoporos Int. 2025 Jan;36(1):103-111. doi: 10.1007/s00198-024-07288-x. Epub 2024 Nov 12.
The prevalence of AAC in patients attending a Fracture Liaison Service is 27.6%. Prevalent vertebral fractures were associated with AAC, but not with severe AAC in patients without CVD. Fracture location and BMD were not related to AAC or severe AAC.
Abdominal aortic calcification (AAC) is associated with an increased risk of cardiovascular disease (CVD), osteoporosis and fractures. We aimed to analyze the prevalence and severity of AAC and to assess whether index fracture location, bone mineral density (BMD) and prevalent VFs are associated with AAC in patients with a recent fracture.
Cross-sectional cohort study of patients with a recent clinical fracture (aged 50-90 years) attending the FLS. Patients received a BMD measurement and lateral spine imaging using Dual-energy X-ray absorptiometry. AAC prevalence was assessed using the AAC-24 score and categorized as none, moderate (AAC-24 1-4) and severe (AAC-24 ≥ 5). Multivariate logistic regression analyses were performed to study the association between risk factors and AAC presence/ severity.
AAC was present in 478 (27.6%) of 1731 patients of whom 207 (43.3%) had moderate and 271 (56.7%) severe AAC. The presence of AAC was associated with age, BMI, smoking, history of CVD and prevalent grade 2 or 3 VFs, but index fracture location and BMD were not associated with AAC or severe AAC. In patients with AAC (n = 318) without a history of CVD, there was no association between index fracture location and BMD. In that subgroup, severe AAC was not associated with prevalent VFs.
In FLS patients, the prevalence of AAC and severe AAC was 27.6% and 15.7%. Index fracture location and BMD were not associated with AAC or severe AAC. Prevalent VFs were associated with AAC, but not with severe AAC in the subgroup of patients without CVD.
在骨折联络服务中心就诊的患者中，腹主动脉钙化（AAC）的患病率为27.6%。在无心血管疾病（CVD）的患者中，现患椎体骨折与AAC有关，但与严重AAC无关。骨折部位和骨密度与AAC或严重AAC无关。
腹主动脉钙化（AAC）与心血管疾病（CVD）、骨质疏松症和骨折风险增加有关。我们旨在分析AAC的患病率和严重程度，并评估近期骨折患者的骨折部位、骨矿物质密度（BMD）和现患椎体骨折是否与AAC有关。
对骨折联络服务中心（FLS）的近期临床骨折患者（年龄50 - 90岁）进行横断面队列研究。患者接受双能X线吸收法测量骨密度和脊柱侧位成像。使用AAC - 24评分评估AAC患病率，并分为无、中度（AAC - 24为1 - 4）和重度（AAC - 24≥5）。进行多变量逻辑回归分析以研究危险因素与AAC存在/严重程度之间的关联。
1731例患者中有478例（27.6%）存在AAC，其中207例（43.3%）为中度AAC，271例（56.7%）为重度AAC。AAC的存在与年龄、体重指数、吸烟、CVD病史和现患2级或3级椎体骨折有关，但骨折部位和骨密度与AAC或重度AAC无关。在无CVD病史的AAC患者（n = 318）中，骨折部位和骨密度之间无关联。在该亚组中，重度AAC与现患椎体骨折无关。
在骨折联络服务中心的患者中，AAC和重度AAC的患病率分别为27.6%和15.7%。骨折部位和骨密度与AAC或重度AAC无关。在无CVD的患者亚组中，现患椎体骨折与AAC有关，但与重度AAC无关。
