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一种新型HA/β-TCP-胶原复合材料促进比格犬拔牙窝保存中的新骨形成

A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs.

作者信息

Ho Ko-Ning, Salamanca Eisner, Chang Kuo-Chi, Shih Tsai-Chin, Chang Yu-Chi, Huang Haw-Ming, Teng Nai-Chia, Lin Che-Tong, Feng Sheng-Wei, Chang Wei-Jen

机构信息

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan.

出版信息

Materials (Basel). 2016 Mar 11;9(3):191. doi: 10.3390/ma9030191.

DOI:10.3390/ma9030191
PMID:28773317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456700/
Abstract

Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction.

摘要

过去对人类的研究表明，拔牙后六个月会出现水平和垂直骨吸收。已经开发出许多生物材料来在拔牙后保留骨量。I型胶原蛋白是生长因子的优良递送系统，并能促进血管生成。磷酸钙陶瓷也因其矿物化学性质与人类骨骼相似而得到研究。本研究的目的是比较一种新型可生物吸收的纯化纤维状胶原蛋白与羟基磷灰石/β-磷酸三钙（HA/β-TCP）陶瓷复合材料、单独的胶原蛋白以及牛异种移植物-胶原蛋白复合材料在比格犬体内的性能。将胶原蛋白塞、牛移植物-胶原蛋白复合材料和HA/β-TCP-胶原蛋白复合材料植入左右两侧的第一、第二和第三下颌前磨牙，第四磨牙留空以进行自然愈合。总共使用了20只雄性比格犬，并对拔牙窝进行了定量和组织学分析。在第8周时，HA/β-TCP-胶原蛋白复合材料导致的牙槽嵴宽度减小最小，为19.09%±8.81%，并且在第4周和第8周伴有新骨形成。作为一种新型的骨传导和仿生复合生物材料，HA/β-TCP-胶原蛋白复合材料在拔牙后牙槽骨保存方面表现良好。

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