Ros-Tárraga Patricia, Mazón Patricia, Meseguer-Olmo Luis, De Aza Piedad N
Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n. Elche, Alicante 03202, Spain.
Departamento de Materiales, Óptica y Tecnologia Electrónica, Universidad Miguel Hernández, Avda. Universidad s/n, Elche (Alicante) 03202, Spain.
Materials (Basel). 2016 Apr 28;9(5):322. doi: 10.3390/ma9050322.
The subsystem Nurse's A-phase-silicocarnotite within the system Ca₃(PO₄)₂-Ca₂SiO₄ was conducted as a preliminary step toward obtaining new biomaterials with controlled microstructures. Phase composition of the resulting ceramics was studied by X-ray diffraction, differential thermal analysis, and scanning electron microscopy with attached wavelength dispersive spectroscopy. The results showed that the sub-system presents an invariant eutectoid point at 1366 ± 4 °C with a composition of 59.5 wt % Ca₃(PO₄)₂ and 40.5 wt % Ca₂SiO₄, and typical eutectoid microstructure of lamellae morphology. These results are in disagreement with the previous reported data, which locate the invariant eutectoid point at 1250 ± 20 °C with a composition of 55 wt % Ca₃(PO₄)₂ and 45 wt % Ca₂SiO₄. In addition, cell attachment testing showed that the new eutectoid material supported the mesenchymal stem cell adhesion and spreading, and the cells established close contact with the ceramic after 28 days of culture. These findings indicate that the new ceramic material with eutectoid microstructure of lamellae morphology possesses good bioactivity and biocompatibility and might be a promising bone implant material.
作为获得具有可控微观结构的新型生物材料的初步步骤，对Ca₃(PO₄)₂ - Ca₂SiO₄体系中的子体系护士A相硅钙钛矿进行了研究。通过X射线衍射、差热分析以及配备波长色散光谱仪的扫描电子显微镜对所得陶瓷的相组成进行了研究。结果表明，该子体系在1366 ± 4 °C处呈现一个不变共析点，其组成为59.5 wt%的Ca₃(PO₄)₂和40.5 wt%的Ca₂SiO₄，具有典型的片状共析微观结构。这些结果与先前报道的数据不一致，先前报道的数据将不变共析点定位在1250 ± 20 °C，组成为55 wt%的Ca₃(PO₄)₂和45 wt%的Ca₂SiO₄。此外，细胞附着测试表明，这种新型共析材料支持间充质干细胞的黏附和铺展，并且在培养28天后细胞与陶瓷建立了紧密接触。这些发现表明，具有片状共析微观结构的新型陶瓷材料具有良好的生物活性和生物相容性，可能是一种有前景的骨植入材料。
