类组织体模作为插入式荧光纳米探针的平台

Nayhoz Tsviya, Barnoy Eran A, Fixler Dror

Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 5290002, Israel.

Materials (Basel). 2016 Nov 15;9(11):926. doi: 10.3390/ma9110926.

Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents.

组织样体模被广泛用作模拟活组织光学特性的模型。本文介绍了对溶液中以及插入固体组织模拟体模中的荧光素共轭金纳米棒进行扩散反射法和荧光寿命成像显微镜测量的结果。溶液和体模的荧光寿命结果缺乏一致性，这引发了一个问题，即组织样体模能否维持插入的造影剂的光学特性。