Bar-Ilan University, Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Ramat-Gan 52900, Israel.
J Biomed Opt. 2013 Jun;18(6):61226. doi: 10.1117/1.JBO.18.6.061226.
The ability to quantitatively and noninvasively detect nanoparticles nearby the skin surface has important implications on their development as an in vivo cancer diagnostic tool. The diffusion reflection (DR) method is a simple, noninvasive imaging technique which has been proven useful for the investigation of the optical parameters of the tissue. A new method is presented for the measurements of gold nanorod (GNR) concentration in tissue-like phantoms, based on DR measurement and intense light absorption of GNR. Monte Carlo simulations and tissue-like phantom measurements of the reflected light intensity are presented. The ability to extract optical properties of phantoms and their GNR concentrations from DR measurements is demonstrated, followed by a discussion about the best mathematical model for light propagation in tissues, based on the diffusion theory.
定量且无创地检测皮肤表面附近的纳米颗粒的能力对于它们作为体内癌症诊断工具的发展具有重要意义。扩散反射（DR）方法是一种简单、无创的成像技术，已被证明可用于研究组织的光学参数。提出了一种基于 DR 测量和金纳米棒（GNR）强烈光吸收的新方法，用于测量类组织体模中的 GNR 浓度。给出了反射光强度的蒙特卡罗模拟和类组织体模测量结果。结果表明，能够从 DR 测量中提取体模和其 GNR 浓度的光学特性，然后根据扩散理论讨论用于组织中光传播的最佳数学模型。
