Salamanca Eisner, Tsai Chi-Yang, Pan Yu-Hwa, Lin Yu-Te, Huang Haw-Ming, Teng Nai-Chia, Lin Che-Tong, Feng Sheng-Wei, Chang Wei-Jen
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Dental Department, Taipei Medical University Hospital, Taipei 110, Taiwan.
Materials (Basel). 2016 Nov 22;9(11):949. doi: 10.3390/ma9110949.
For years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study's main objective was to achieve space maintenance and bone regeneration using a new freeze-dried developed porcine collagen membrane, and compare it with an already commercial collagen membrane, when both were used with a bovine xenograft in prepared alveolar ridge bone defects. Prior to surgery, the membrane's vitality analysis showed statistically significant higher cell proliferation in the test membrane over the commercial one. In six beagle dogs, commercial bone xenograft was packed in lateral ridge bone defects prepared in the left and right side and then covered with test porcine collagen membrane or commercial collagen membrane. Alveolar height changes were measured. Histomorphometric results, in vitro and in vivo properties indicated that the new porcine collagen membrane is biocompatible, enhances bone xenograft osteoconduction, and reduces the alveolar ridge height reabsorption rate.
多年来，为了改善骨再生并避免二期手术移除不可吸收膜的需求，生物可吸收膜逐渐得到开发并应用于引导组织再生（GTR）。本研究的主要目的是使用一种新研发的冻干猪胶原蛋白膜实现空间维持和骨再生，并将其与一种已商业化的胶原蛋白膜进行比较，当两者都与牛异种移植物一起用于制备的牙槽嵴骨缺损时。手术前，膜的活力分析显示，测试膜中的细胞增殖在统计学上显著高于商业膜。在六只比格犬中，将商业骨异种移植物填充到左右两侧制备的侧牙槽嵴骨缺损中，然后用测试猪胶原蛋白膜或商业胶原蛋白膜覆盖。测量牙槽嵴高度变化。组织形态计量学结果、体外和体内特性表明，新的猪胶原蛋白膜具有生物相容性，增强了骨异种移植物的骨传导性，并降低了牙槽嵴高度吸收速率。
