Wang Hsiuying
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Polymers (Basel). 2021 Nov 9;13(22):3868. doi: 10.3390/polym13223868.
Collagen, an abundant extracellular matrix protein, has been found to have a lot of pharmaceuticals, medicine, food, and cosmetics applications. Increased knowledge of collagen sources, extraction techniques, structure, and properties in the last decades has helped develop more collagen-based products and tissue engineering biomaterials. Collagen products have been playing an important role in benefiting the health of the human body, especially for aging people. In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies. In addition, the associations between these diseases were discussed. The comorbidity of these diseases might be closely related to collagen deficiency, and collagen treatment might be a good choice when a patient has more than one of these diseases, including the coronavirus disease 2019 (COVID-19). It concludes that collagen-based medication is useful in treating comorbid diseases and preventing complications.
胶原蛋白是一种丰富的细胞外基质蛋白，已被发现有许多制药、医学、食品和化妆品应用。在过去几十年里，人们对胶原蛋白来源、提取技术、结构和特性的了解不断增加，这有助于开发更多基于胶原蛋白的产品和组织工程生物材料。胶原蛋白产品在促进人体健康方面发挥着重要作用，尤其是对老年人。本文综述了胶原蛋白治疗在不同临床研究中的效果，包括皮肤再生、骨缺损、肌肉减少症、伤口愈合、牙科治疗、胃食管反流、骨关节炎和类风湿性关节炎。在这些临床研究中，胶原蛋白治疗效果显著。此外，还讨论了这些疾病之间的关联。这些疾病的合并症可能与胶原蛋白缺乏密切相关，当患者患有不止一种这些疾病，包括2019冠状病毒病（COVID-19）时，胶原蛋白治疗可能是一个不错的选择。研究得出结论，基于胶原蛋白的药物在治疗合并症和预防并发症方面是有用的。
