Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Department of Psychology, Mayo Clinic, Rochester, Minnesota.
Am J Physiol Gastrointest Liver Physiol. 2020 Aug 1;319(2):G238-G244. doi: 10.1152/ajpgi.00140.2020. Epub 2020 Jul 6.
Whereas gastric emptying significantly predicts calorie intake, the association between gastric capacity and satiation and satiety is unclear. To study the associations between gastric volumes and ingestive behaviors with satiation and satiety in obesity, 62 healthy adult obese patients (57 female) with no eating disorders underwent measurements of satiety, as determined by kilocalories of ingestion at a buffet meal, and satiation by volume to comfortable fullness (VTF) and maximum tolerated volume (MTV), while drinking Ensure (30 mL/min). Fasting and postprandial gastric volumes were measured by validated single-photon emission computed tomography. We also measured eating [Weight Efficacy Life-Style Questionnaire score (WEL)] and exercise behaviors associated with obesity. Spearman correlation-assessed relationships of measured traits and linear regression analysis to identify predictors of satiation or satiety. The participants were aged 38 ± 10.1 yr and the body mass index (BMI) 36.8 ± 4.8 kg/m. Fasting gastric volume was significantly correlated with VTF ( = 0.3, = 0.03), but not with MTV or buffet meal kilocalorie ingestion. Regression analysis identified sex ( = 0.02, with males having significantly higher fasting gastric volume) and fasting gastric volume (0.04) as predictors of higher VTF. An increase in fasting gastric volume of 50 mL resulted in a 6-mL increase in VTF. Buffet meal intake was inversely related to the ability to resist the urge to eat; factors associated with ingestive behavior (increase in total WEL score) significantly correlated with satiety and gastric accommodation ( < 0.05). Gastric capacity during fasting is associated with calorie intake to the point of comfortable fullness; factors associated with ingestive behavior are associated with satiety and gastric accommodation. Buffet meal intake was inversely related to the ability to resist the urge to overeat. Factors associated with ingestive behavior significantly correlated with satiety and gastric accommodation. Gastric capacity during fasting is associated with calorie intake to the point of comfortable fullness; factors associated with ingestive behavior are associated with satiety and gastric accommodation.
尽管胃排空明显预测热量摄入，但胃容量与饱腹感和饱足感之间的关系尚不清楚。为了研究胃容量与饱腹感和饱足感之间的关系，我们对 62 名健康的成年肥胖患者（57 名女性，无饮食失调症）进行了餐点摄入热量的饱腹感测定，以及通过容量达到舒适饱腹感（VTF）和最大耐受容量（MTV）的饱腹感测定，同时饮用 Ensure（30 毫升/分钟）。空腹和餐后胃容量通过验证的单光子发射计算机断层扫描进行测量。我们还测量了与肥胖相关的饮食[体重功效生活方式问卷评分（WEL）]和运动行为。使用 Spearman 相关性评估测量特征之间的关系，并进行线性回归分析，以确定饱腹感或饱足感的预测因子。参与者年龄为 38±10.1 岁，体重指数（BMI）为 36.8±4.8kg/m。空腹胃容量与 VTF 呈显著相关（ =0.3， =0.03），但与 MTV 或自助餐摄入的热量无关。回归分析确定了性别（ =0.02，男性空腹胃容量显著较高）和空腹胃容量（0.04）是 VTF 较高的预测因子。空腹胃容量增加 50 毫升可使 VTF 增加 6 毫升。自助餐摄入与抵抗进食冲动的能力呈反比关系；与摄食行为相关的因素（总 WEL 评分增加）与饱腹感和胃顺应性呈显著相关（<0.05）。空腹时的胃容量与摄入舒适饱腹感的卡路里量有关；与摄食行为相关的因素与饱腹感和胃顺应性有关。自助餐摄入与抵抗暴饮暴食的能力呈反比关系；与摄食行为相关的因素与饱腹感和胃顺应性呈显著相关。空腹时的胃容量与摄入舒适饱腹感的卡路里量有关；与摄食行为相关的因素与饱腹感和胃顺应性有关。
