Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.
Precision Medicine for Obesity Program, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Int J Obes (Lond). 2022 Dec;46(12):2156-2162. doi: 10.1038/s41366-022-01228-7. Epub 2022 Oct 13.
Satiation is a key component of food intake regulation as it brings an eating episode to an end. The effect of sex on satiation measurement has not been characterized.
To assess the effects of biological variables on satiation.
Retrospective cohort study. We included 959 participants (mean age 39 [SD 12] years; 70.7% female, and BMI 33 kg/m [8]) who had measurements of satiation with a nutrient-drink test to assess volume to fullness (VTF) and maximum tolerated volume (MTV), and/or an ad libitum meal test to assess calories consumed to fullness (CTF). We performed univariate and multiple regression analyses to estimate the contribution of sex to VTF, MTV, and CTF, compared to other biological variables, such as age, weight, height, BMI, waist-to-hip circumference (W/H), and lean mass percentage (LM%), that are known to affect these parameters.
Females had higher BMI, W/H, and LM%. VTF, MTV, and CTF were lower in females: 704 [323] vs. 783 [328] mL, p = 0.001; 1226 [384] vs. 1419 [410] mL, p < 0.001; and 871 [291] vs. 1086 [326] kcal, p < 0.001; respectively. Sex was a strong and independent predictor of VTF, MTF and CTF: parameter estimate [PE] = -80.8, p = 0.006; PE = -124.2, p = 0.0007; and PE = -110, p = 0.001; respectively.
Sex has a strong effect on satiation measured by VTF, MTV, and CTF, even after adjusting for other biological factors known to affect these parameters. Females seem to integrate intra-meal inhibition signals to consume fewer calories unrelated to body size or composition.
None.
饱食感是进食调节的一个关键组成部分，因为它会结束一次进食。性别的不同会影响饱食感的测量，但其影响尚未被描述。
评估生物变量对饱食感的影响。
回顾性队列研究。我们纳入了 959 名参与者（平均年龄 39 [12]岁；70.7%为女性，BMI 为 33kg/m [8]），他们接受了营养饮料测试来评估容量饱腹感（VTF）和最大耐受量（MTV），或自由进食测试来评估饱腹感时摄入的卡路里量（CTF）。我们进行了单变量和多变量回归分析，以评估性别对 VTF、MTV 和 CTF 的影响，与其他已知会影响这些参数的生物变量（如年龄、体重、身高、BMI、腰围-臀围比（W/H）和瘦体重百分比（LM%））相比。
女性的 BMI、W/H 和 LM%更高。女性的 VTF、MTV 和 CTF 较低：704 [323] vs. 783 [328] mL，p = 0.001；1226 [384] vs. 1419 [410] mL，p < 0.001；871 [291] vs. 1086 [326] kcal，p < 0.001；分别。性别是 VTF、MTF 和 CTF 的一个强有力的独立预测因素：参数估计值[PE] = -80.8，p = 0.006；PE = -124.2，p = 0.0007；PE = -110，p = 0.001；分别。
即使在调整了其他已知会影响这些参数的生物因素后，性别对 VTF、MTV 和 CTF 测量的饱食感仍有很强的影响。女性似乎整合了进食过程中的抑制信号，摄入较少与身体大小或组成无关的卡路里。
无。
