Wik G, Wiesel F A, Eneroth P, Sedvall G, Aström G
Acta Psychiatr Scand. 1986 Aug;74(2):161-7. doi: 10.1111/j.1600-0447.1986.tb10600.x.
The dexamethasone suppression test (DST) was performed in 21 drug-free schizophrenic patients. The patients satisfied DSM-III and Research Diagnostic Criteria for schizophrenia and were in an acute phase of the disease. In 15 of the patients the DST was repeated after about 5 weeks of treatment with neuroleptics. DST compliance was checked by analysis of dexamethasone concentrations in plasma. In the acute phase 71% (at 04 p.m.) of the patients were nonsuppressors. After neuroleptic treatment the frequency of abnormal responders had decreased to 20%. The decrease in nonsuppressors was not due to alteration of the dexamethasone concentration between the two test occasions. Prolactin levels were markedly increased at the second test occasion compared with the first. There were no significant relationships between cortisol levels, cortisol suppression and prolactin levels. The high frequency of nonsuppressors among schizophrenic patients in the acute phase of the disease indicates that acute stress may be a confounding factor in the outcome of DST.
对21例未服用药物的精神分裂症患者进行了地塞米松抑制试验（DST）。这些患者符合DSM-III和精神分裂症的研究诊断标准，且处于疾病急性期。其中15例患者在使用抗精神病药物治疗约5周后重复进行了DST。通过分析血浆中地塞米松浓度来检查DST的依从性。急性期时，71%（下午4点时）的患者为非抑制者。抗精神病药物治疗后，异常反应者的频率降至20%。非抑制者的减少并非由于两次测试期间地塞米松浓度的改变。与第一次测试相比，第二次测试时催乳素水平显著升高。皮质醇水平、皮质醇抑制与催乳素水平之间无显著相关性。疾病急性期精神分裂症患者中非抑制者的高频率表明，急性应激可能是DST结果的一个混杂因素。
