Schönfeld Andreas, Feldt Torsten, Tufa Tafese B, Orth Hans M, Fuchs André, Mesfun Million G, Pfäfflin Frieder, Nordmann Tamara, Breuer Matthias, Hampl Monika, Häussinger Dieter
1 Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, Germany.
2 Hirsch Institute of Tropical Medicine, Department of Gastroenterology, Hepatology and Infectious Diseases in cooperation with Arsi University, Asella, Ethiopia.
Int J STD AIDS. 2018 Mar;29(3):251-258. doi: 10.1177/0956462417723545. Epub 2017 Aug 4.
Human immunodeficiency virus (HIV) continues to be a major global public health issue and omnipresent sexually transmitted infections (STIs) increase the risk of HIV acquisition. Moreover, STIs and HIV in pregnant women can harm the unborn child. In this study, we systematically investigated the prevalence of HIV, relevant STIs and vaginal group B streptococcus colonization among pregnant women presenting at Asella Teaching Hospital in central Ethiopia and their effect on perinatal mortality. A follow-up was performed six weeks after delivery. A total of 580 women were included, of which 26.6% tested positive for at least one pathogen ( Chlamydia trachomatis 9.8%, trichomoniasis 5.3%, hepatitis B 5.3%, gonorrhoea 4.3%, group B streptococcus 2.4%, syphilis 2.2%, HIV 2.1%). None of the HIV infections were previously undiagnosed, indicating effective HIV screening activities in the region. Follow-up data were available for 473 (81.6%) children, of which 37 (7.8%) were stillborn or died within the first six weeks of life. Infection with Trichomonas vaginalis and recruitment at obstetric ward (versus antenatal care) were associated with mortality. High prevalence of STIs in pregnant women and their impact on the unborn child demonstrate the need for screening and treatment programmes in order to prevent perinatal mortality.
人类免疫缺陷病毒（HIV）仍然是一个主要的全球公共卫生问题，无处不在的性传播感染（STIs）会增加感染HIV的风险。此外，孕妇感染性传播感染和HIV会对未出生的孩子造成伤害。在本研究中，我们系统调查了埃塞俄比亚中部阿塞拉教学医院就诊的孕妇中HIV、相关性传播感染及阴道B族链球菌定植的患病率及其对围产期死亡率的影响。在分娩后六周进行随访。共纳入580名妇女，其中26.6%至少对一种病原体检测呈阳性（沙眼衣原体9.8%、滴虫病5.3%、乙型肝炎5.3%、淋病4.3%、B族链球菌2.4%、梅毒2.2%、HIV 2.1%）。所有HIV感染之前均已确诊，表明该地区有效的HIV筛查活动。473名（81.6%）儿童有随访数据，其中37名（7.8%）为死产或在出生后六周内死亡。感染阴道毛滴虫以及在产科病房（相对于产前护理）就诊与死亡率相关。孕妇性传播感染的高患病率及其对未出生孩子的影响表明需要开展筛查和治疗项目以预防围产期死亡。
