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高氯酸镁催化高效合成螺[吲哚啉-3,9'-呫吨]三酮衍生物

An Efficient Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate.

作者信息

Chen Chunfeng, Lv Chunlei, Liang Jianfeng, Jin Jianqing, Wang Lijun, Wu Chunlei, Shen Runpu

机构信息

Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China.

Zhejiang Medicine Co., Ltd., Shaoxing 312000, Zhejiang, China.

出版信息

Molecules. 2017 Aug 4;22(8):1295. doi: 10.3390/molecules22081295.

DOI:10.3390/molecules22081295
PMID:28777350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6152258/
Abstract

A simple and efficient method for the synthesis of spiro[indoline-3,9'-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.

摘要

描述了一种简单有效的方法，即在50%乙醇水溶液介质中，于80℃下，在催化量的高氯酸镁存在下，通过异吲哚酮与1,3 -环己二酮缩合来合成螺[吲哚啉-3,9'-呫吨]三酮衍生物。值得注意的是，本方法具有产率高、后处理程序简单、易于纯化和反应时间缩短等理想优点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a6/6152258/ffbcc47a137a/molecules-22-01295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a6/6152258/248d66155931/molecules-22-01295-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a6/6152258/ffbcc47a137a/molecules-22-01295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a6/6152258/248d66155931/molecules-22-01295-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a6/6152258/ffbcc47a137a/molecules-22-01295-g001.jpg

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