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Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.抗疟药物耐药性：将恶性疟原虫生物学与临床联系起来
Nat Med. 2017 Aug 4;23(8):917-928. doi: 10.1038/nm.4381.
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How genomics is contributing to the fight against artemisinin-resistant malaria parasites.基因组学如何助力对抗青蒿素耐药疟原虫。
Acta Trop. 2015 Aug;148:1-7. doi: 10.1016/j.actatropica.2015.04.007. Epub 2015 Apr 21.
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Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.恶性疟原虫对青蒿素联合疗法的耐药性：疟疾消除之路上的达摩克利斯之剑。
Parasite. 2018;25:24. doi: 10.1051/parasite/2018021. Epub 2018 Apr 20.
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Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure.青蒿素长期压力诱导恶性疟原虫产生多药耐受性。
Emerg Infect Dis. 2015 Oct;21(10):1733-41. doi: 10.3201/eid2110.150682.
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Artemisinin-Resistant Plasmodium falciparum Malaria.抗青蒿素疟原虫疟疾。
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0013-2016.
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Triple Artemisinin-Based Combination Therapies for Malaria - A New Paradigm?三药联合疗法治疗疟疾——一种新模式？
Trends Parasitol. 2021 Jan;37(1):15-24. doi: 10.1016/j.pt.2020.09.011. Epub 2020 Oct 12.
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Artemisinin derivatives and malaria: useful, in combination with other antimalarials.青蒿素衍生物与疟疾：与其他抗疟药物联合使用时有效。
Prescrire Int. 2008 Aug;17(96):162-8.
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Antimalarial drug resistance in Africa: the calm before the storm?非洲的抗疟药物耐药性：暴风雨前的平静？
Lancet Infect Dis. 2019 Oct;19(10):e338-e351. doi: 10.1016/S1473-3099(19)30261-0. Epub 2019 Jul 30.
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Artemisinin Action and Resistance in Plasmodium falciparum.青蒿素在恶性疟原虫中的作用与耐药性
Trends Parasitol. 2016 Sep;32(9):682-696. doi: 10.1016/j.pt.2016.05.010. Epub 2016 Jun 9.
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Artemisinin resistance in Plasmodium falciparum: what is it really?疟原虫对青蒿素的抗药性：它到底是什么？
Trends Parasitol. 2013 Jul;29(7):318-20. doi: 10.1016/j.pt.2013.05.002. Epub 2013 Jun 11.
引用本文的文献
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Novel Inhibitors of Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and Efficacy in a Humanized Mouse Malaria Infection Model.新型磷脂酰肌醇4激酶IIIβ抑制剂，耐药倾向低：在人源化小鼠疟疾感染模型中的生命周期阶段活性和疗效
J Med Chem. 2025 Aug 28;68(16):17736-17751. doi: 10.1021/acs.jmedchem.5c01417. Epub 2025 Aug 14.
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Antimalarial activity of root extract of Tephrosia villosa L. Pers. (Fabaceae) on Plasmodium berghei-infected mice.绒毛灰叶（豆科）根提取物对感染伯氏疟原虫小鼠的抗疟活性。
Sci Rep. 2025 Jul 25;15(1):27162. doi: 10.1038/s41598-025-11137-0.
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Direct long-read visualization reveals hidden variation in GCH1 gene copy number and precise expansion steps.直接长读长可视化揭示了GCH1基因拷贝数的隐藏变异和精确的扩增步骤。
BMC Genomics. 2025 Jul 17;26(1):671. doi: 10.1186/s12864-025-11859-5.
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Comprehensive genomic study of Plasmodium falciparum in Sierra leone: genetic variation and resistance patterns.塞拉利昂恶性疟原虫的综合基因组研究：遗传变异与抗药模式
BMC Genomics. 2025 Jul 1;26(1):584. doi: 10.1186/s12864-025-11771-y.
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Malaria: past, present, and future.疟疾：过去、现在与未来。
Signal Transduct Target Ther. 2025 Jun 17;10(1):188. doi: 10.1038/s41392-025-02246-3.
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A comprehensive review of cerebral malaria.脑型疟疾的全面综述。
J Parasit Dis. 2025 Jun;49(2):257-272. doi: 10.1007/s12639-024-01758-z. Epub 2024 Nov 15.
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Emerging Plasmodium falciparum K13 gene mutation to artemisinin-based combination therapies and partner drugs among malaria-infected population in sub-Saharan Africa.撒哈拉以南非洲疟疾感染人群中恶性疟原虫K13基因对青蒿素联合疗法及相关药物的新出现突变
Parasites Hosts Dis. 2025 May;63(2):109-122. doi: 10.3347/PHD.24053. Epub 2025 May 26.
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Repurposing antimalarials: pyrimethamine exhibits superior in vitro activity to metronidazole against Gardnerella while sparing Lactobacillus.重新利用抗疟药：乙胺嘧啶在体外对加德纳菌的活性优于甲硝唑，同时对乳酸杆菌无损害。
J Antimicrob Chemother. 2025 Jul 1;80(7):1972-1979. doi: 10.1093/jac/dkaf157.
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The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound.恶性疟原虫快速进化的FIKK激酶家族可被单一化合物抑制。
Nat Microbiol. 2025 May 19. doi: 10.1038/s41564-025-02017-4.
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The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria.ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4激酶（PI4Kβ）的强效抑制剂，是抗疟疾药物化学优化的有吸引力的候选物。
Angew Chem Int Ed Engl. 2025 Jul 7;64(28):e202425206. doi: 10.1002/anie.202425206. Epub 2025 May 15.
本文引用的文献
1
Protein Degradation Systems as Antimalarial Therapeutic Targets.蛋白质降解系统作为抗疟治疗靶点
Trends Parasitol. 2017 Sep;33(9):731-743. doi: 10.1016/j.pt.2017.05.009. Epub 2017 Jul 5.
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.一种基于四氧杂环烷的抗疟药物候选物，可克服 PfK13-C580Y 依赖性青蒿素耐药性。
Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.
3
A Variant PfCRT Isoform Can Contribute to Resistance to the First-Line Partner Drug Piperaquine.一种变异的疟原虫氯喹抗性转运蛋白（PfCRT）异构体可能导致对一线联合用药磷酸哌喹产生耐药性。
mBio. 2017 May 9;8(3):e00303-17. doi: 10.1128/mBio.00303-17.
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Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons.疟疾与青蒿素联合疗法中的氧化应激：利弊
FEBS J. 2017 Aug;284(16):2579-2591. doi: 10.1111/febs.14097. Epub 2017 May 25.
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Antimalarial efficacy of MMV390048, an inhibitor of phosphatidylinositol 4-kinase.磷脂酰肌醇4激酶抑制剂MMV390048的抗疟疗效
Sci Transl Med. 2017 Apr 26;9(387). doi: 10.1126/scitranslmed.aad9735.
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K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness .K13突变对臭氧敏感性和寄生虫适应性有不同影响。
mBio. 2017 Apr 11;8(2):e00172-17. doi: 10.1128/mBio.00172-17.
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Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis.葡萄糖-6-磷酸脱氢酶缺乏与疟疾的关系：系统评价和荟萃分析。
Sci Rep. 2017 Apr 6;7:45963. doi: 10.1038/srep45963.
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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.新型长效抗疟药DSM265的安全性、耐受性、药代动力学及活性：一项分为两部分的首次人体1a/1b期随机研究
Lancet Infect Dis. 2017 Jun;17(6):626-635. doi: 10.1016/S1473-3099(17)30171-8. Epub 2017 Mar 28.
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Targeting the Parasite to Suppress Malaria Transmission.靶向寄生虫以抑制疟疾传播。
Adv Parasitol. 2017;97:147-185. doi: 10.1016/bs.apar.2016.09.004. Epub 2016 Nov 12.
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Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.甲氟喹靶向疟原虫 80S 核糖体以抑制蛋白质合成。
Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31.
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