胆管细胞：不再是肝再生反应的灰姑娘。
Cholangiocytes: No Longer Cinderellas to the Hepatic Regenerative Response.
机构信息
Centre for Tumour Biology, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
出版信息
Cell Stem Cell. 2017 Aug 3;21(2):159-160. doi: 10.1016/j.stem.2017.07.002.
PMID:28777941
Abstract
Biliary ductal cells proliferate from the portal areas of chronically damaged livers, but their significance to regeneration has been controversial. A recent article in Nature by Raven et al. (2017) now shows that blocking hepatocyte replication is essential for the hepatic differentiation of ductular cells after liver damage.
摘要
胆管细胞从慢性损伤肝脏的门脉区域增殖，但它们对肝再生的意义一直存在争议。Raven 等人在《自然》杂志上的一篇最新文章（2017 年）表明，在肝损伤后，阻断肝细胞复制对于胆管细胞的肝分化是必需的。
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