肝细胞和胆管细胞的再生利他主义。
The Regenerative Altruism of Hepatocytes and Cholangiocytes.
机构信息
Department of Pathology, University of Pittsburgh, Pittsburgh, USA.
出版信息
Cell Stem Cell. 2018 Jul 5;23(1):11-12. doi: 10.1016/j.stem.2018.06.006.
PMID:29979985
Abstract
In this issue of Cell Stem Cell and recently in Nature, Deng et al. (2018) and Schaub et al. (2018) (respectively) demonstrate that following acute liver injury, hepatocytes and cholangiocytes restore liver mass and function. When proliferative capacity of either cell type is impaired, the other cell type will transdifferentiate to restore full regeneration and hepatic histology.
摘要
在本期的《Cell Stem Cell》和最近的《自然》杂志上，邓宏魁等人（2018 年）和绍布等人（2018 年）（分别）表明，在急性肝损伤后，肝细胞和胆管细胞会恢复肝脏的质量和功能。当任何一种细胞类型的增殖能力受损时，另一种细胞类型将会转分化以恢复完全的再生和肝组织学。
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