Department of Preventive Medicine, Gachon University College of Medicine, 191 Hambakmoeiro, Yeonsu-Gu, Incheon, South Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehangno, Chongno-gu, Seoul, South Korea.
Clin Nutr. 2018 Oct;37(5):1675-1682. doi: 10.1016/j.clnu.2017.07.014. Epub 2017 Jul 18.
BACKGROUND & AIMS: To evaluate the relationship between phytoestrogen and colon cancer risk, we quantified plasma isoflavones (Genistein and Daidzein) and lignan (enterolactone) in a Korean nested case-control study and conducted replication study in a Vietnamese case-control study.
Study populations of 101 cases and 391 controls were selected from the Korean Multicenter Cancer Cohort which was constructed from 1993 to 2004. For replication study, Vietnamese hospital-based case-control subjects of 222 cases and 206 controls were selected from 2003 to 2007. The concentrations of plasma genistein, daidzein, and enterolactone were quantified by liquid chromatography-mass spectrometry. Logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs), and meta-analysis was conducted to estimate combined ORs (CORs) and 95% Cis of Korean and Vietnamese population in 2014.
Genistein showed a continual decrease in colorectal cancer risk according to level up of the concentration categories in Korean and Vietnamese population (P for trend = 0.032, and 0.001, respectively) and a significantly decreased risk was found at the highest concentration of genistein and daidzein (for the highest category compared to the lowest: COR (95% CI) = 0.46 (0.30-0.69), and COR (95% CI) = 0.54 (0.36-0.82)). When the study population was stratified, the beneficial relationship of genistein with colorectal cancer was observed regardless of sex and anatomical subtype. However, enterolacton level was not associated with colorectal cancer risk.
High plasma levels of isoflavones had relationship with a decreased risk of colorectal cancer, regardless of different ethnic background.
为了评估植物雌激素与结肠癌风险之间的关系，我们在一项韩国巢式病例对照研究中定量检测了血浆中的异黄酮（染料木黄酮和大豆苷元）和木脂素（肠内酯），并在越南的病例对照研究中进行了复制研究。
从 1993 年至 2004 年建立的韩国多中心癌症队列中选择了 101 例病例和 391 例对照作为研究人群。为了进行复制研究，从 2003 年至 2007 年选择了越南医院为基础的 222 例病例和 206 例对照。使用液相色谱-质谱法定量检测血浆中染料木黄酮、大豆苷元和肠内酯的浓度。使用逻辑回归模型计算比值比（OR）和 95%置信区间（CI），并在 2014 年对韩国和越南人群进行了荟萃分析以估计合并的 OR（COR）和 95%CI。
在韩国和越南人群中，随着浓度类别的升高，染料木黄酮与结直肠癌风险呈连续下降趋势（趋势检验 P 值分别为 0.032 和 0.001），并且在染料木黄酮和大豆苷元浓度最高时风险显著降低（与最低浓度相比，最高浓度的 COR（95%CI）为 0.46（0.30-0.69）和 COR（95%CI）为 0.54（0.36-0.82））。当研究人群分层时，无论性别和解剖亚型如何，染料木黄酮与结直肠癌的有益关系均存在。然而，肠内酯水平与结直肠癌风险无关。
无论种族背景如何，高血浆异黄酮水平与结直肠癌风险降低有关。
