Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehangno, Chongno-gu, Seoul 110-799, Korea.
Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1292-300. doi: 10.1158/1055-9965.EPI-09-1004.
The role of soybean products in gastric cancer risk is not clear in epidemiologic studies due to measurement error from dietary intake questionnaires and due to different degrees of bias according to study design. To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study.
The study population was composed of 131 cases and 393 matched controls within the Korean Multicenter Cancer Cohort. The concentrations of the four biomarkers in the plasma samples were measured using time-resolved fluoroimmunoassay. Conditional and unconditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence intervals (CI).
Median plasma concentrations of genistein (229 nmol/L for controls, 181.8 nmol/L for cases; P=0.07) and daidzein (131.2 nmol/L for controls, 80.5 nmol/L for cases; P=0.04) in cases were lower than in controls, whereas equol concentrations were similar. Compared with the reference group, gastric cancer risk decreased in the highest groups for genistein (OR, 0.54; 95% CI, 0.31-0.93) and daidzein (OR, 0.21; 95% CI, 0.08-0.58). Higher equol concentrations were associated with a decreased risk for gastric cancer (OR, 0.50; 95% CI, 0.27-0.90). The combination of the highest concentrations for each isoflavone category was associated with a 0.09-fold decreased risk for gastric cancer compared with the combination of the lowest concentrations for each category. There was no association between plasma lignan concentrations and gastric cancer.
High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer.
These results suggest a beneficial effect of high soybean product intake for gastric cancer risk.
由于膳食摄入问卷的测量误差以及根据研究设计的不同程度的偏倚，在流行病学研究中，大豆制品在胃癌风险中的作用尚不清楚。为了研究大豆制品与胃癌风险之间的关系，我们在一项巢式病例对照研究中测量了植物雌激素生物标志物。
研究人群由韩国多中心癌症队列中的 131 例病例和 393 例匹配对照组成。使用时间分辨荧光免疫测定法测量血浆样本中四种生物标志物的浓度。使用条件和非条件逻辑回归模型计算比值比（OR）和 95％置信区间（CI）。
病例组血浆中染料木黄酮（对照组中位数为 229nmol/L，病例组为 181.8nmol/L；P=0.07）和大豆黄素（对照组中位数为 131.2nmol/L，病例组为 80.5nmol/L；P=0.04）的浓度中位数低于对照组，而结合物浓度相似。与参考组相比，大豆异黄酮浓度最高组的胃癌风险降低：染料木黄酮（OR，0.54；95％CI，0.31-0.93）和大豆黄素（OR，0.21；95％CI，0.08-0.58）。较高的结合物浓度与胃癌风险降低相关（OR，0.50；95％CI，0.27-0.90）。与每种类异黄酮类别最低浓度的组合相比，每种类异黄酮浓度最高的组合与胃癌风险降低 0.09 倍相关。血浆木脂素浓度与胃癌之间无关联。
高血清异黄酮浓度与胃癌风险降低相关。
这些结果表明，大豆制品摄入量高对胃癌风险有有益的影响。
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