Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehakro, Jongnogu, Seoul 03080, Korea.
Department of Biomedical Science, College of Medicine, Seoul National University, 103 Daehakro, Jongnogu, Seoul 03080, Korea.
Nutrients. 2021 Dec 5;13(12):4366. doi: 10.3390/nu13124366.
In order to examine the association between plasma phytoestrogen concentration (genistein, daidzein, equol and enterolactone) and hypertension, we conducted a nested case-control study for 229 hypertension cases including 112 prehypertension and 159 healthy controls derived from the Korean Multi-center Cancer Cohort (KMCC). The concentration of plasma phytoestrogens was measured using time-resolved fluoroimmunoassay. We assessed the association between plasma phytoestrogens and hypertension using logistic regression models using odds ratio (OR) and 95% confidence interval (95%CI). The highest tertile of plasma equol and enterolactone concentration exhibited a significantly decreased risk of hypertension (equol, OR = 0.34, 95%CI 0.20-0.57; enterolactone, OR = 0.32, 95%CI 0.18-0.57), compared with the lowest tertile. Equol and enterolactone showed reduced ORs for prehypertension (the highest tertile relative to the lowest tertile, OR = 0.50, 95%CI 0.26-0.96; OR = 0.38, 95%CI 0.19-0.75, respectively) and hypertension (OR = 0.42, 95%CI 0.22-0.81; OR = 0.28, 95%CI 0.14-0.54, respectively). There was a stronger association in hypertension (the highest tertile relative to the lowest tertile in obesity vs. non-obesity; equol, OR = 0.06 vs. 0.63; enterolactone, OR = 0.07 vs. 0.46; both -heterogeneity < 0.01). This study suggests that equol and enterolactone may contribute to prevent primarily prehypertension and hypertension, and control cardiovascular disease (CVD) based on the continuum of hypertension and CVD. Further study to assess hypertension risk based on useful biomarkers, including phytoestrogens, may contribute to primary prevention of hypertension.
为了研究血浆植物雌激素浓度（染料木黄酮、大豆苷元、雌马酚和肠内乳酮）与高血压之间的关系，我们对韩国多中心癌症队列（KMCC）中的 229 例高血压病例（包括 112 例高血压前期和 159 例健康对照者）进行了一项巢式病例对照研究。使用时间分辨荧光免疫测定法测量血浆植物雌激素的浓度。我们使用逻辑回归模型使用比值比（OR）和 95%置信区间（95%CI）评估了血浆植物雌激素与高血压之间的关系。血浆雌马酚和肠内乳酮浓度最高三分位组的高血压风险显著降低（雌马酚，OR=0.34，95%CI 0.20-0.57；肠内乳酮，OR=0.32，95%CI 0.18-0.57），与最低三分位组相比。雌马酚和肠内乳酮对高血压前期（最高三分位组与最低三分位组相比，OR=0.50，95%CI 0.26-0.96；OR=0.38，95%CI 0.19-0.75）和高血压（OR=0.42，95%CI 0.22-0.81；OR=0.28，95%CI 0.14-0.54）的比值比降低。在高血压中，这种相关性更强（肥胖与非肥胖相比，最高三分位组与最低三分位组相比；雌马酚，OR=0.06 对 0.63；肠内乳酮，OR=0.07 对 0.46；两者的异质性均<0.01）。本研究表明，雌马酚和肠内乳酮可能有助于预防原发性高血压前期和高血压，并基于高血压和心血管疾病的连续性控制心血管疾病（CVD）。进一步评估基于有用生物标志物（包括植物雌激素）的高血压风险的研究可能有助于原发性高血压的预防。
