Piller Regina, Chang-Claude Jenny, Linseisen Jakob
Unit of Human Nutrition and Cancer Prevention, Technical University of Munich, and German Cancer Research Center, Department of Clinical Epidemiology, Heidelberg, Germany.
Eur J Cancer Prev. 2006 Jun;15(3):225-32. doi: 10.1097/01.cej.0000197449.56862.75.
The scientific debate on the role of dietary phytoestrogens for prevention of breast cancer is still ongoing. We previously reported an inverse association between dietary phytoestrogen intake and premenopausal breast cancer risk and now examine the relationship with plasma phytoestrogen concentrations.
We measured enterolactone (mammalian lignan) and genistein (isoflavone) concentrations in plasma samples of 220 premenopausal cases and 237 age-matched controls from a population-based case-control study in Germany.
Median plasma enterolactone concentrations in cases and controls were 6.3 and 9.7 nmol/l, respectively, and median genistein concentrations were 4.5 and 3.7 nmol/l, respectively. Premenopausal breast cancer risk decreased with increasing plasma enterolactone concentrations. Adjusted odds ratios (95% confidence intervals) were 0.42 (0.20-0.90) and 0.38 (0.17-0.85) (P for trend 0.007) for women in the third and fourth quartile of plasma enterolactone compared to those in the lowest quartile. There was no significant association between plasma genistein concentration and premenopausal breast cancer risk.
Using biomarkers of phytoestrogen intake, we confirmed the strong inverse association between enterolactone and premenopausal breast cancer risk as found with dietary intake estimates. This result gives support to the potential role of mammalian lignans for breast cancer prevention among premenopausal women in Western populations.
关于膳食植物雌激素在预防乳腺癌中作用的科学争论仍在继续。我们之前报道了膳食植物雌激素摄入量与绝经前乳腺癌风险之间的负相关关系，现在研究其与血浆植物雌激素浓度的关系。
在德国一项基于人群的病例对照研究中，我们测量了220例绝经前病例和237例年龄匹配对照的血浆样本中肠内酯（哺乳动物木脂素）和染料木黄酮（异黄酮）的浓度。
病例组和对照组血浆肠内酯浓度中位数分别为6.3和9.7 nmol/l，染料木黄酮浓度中位数分别为4.5和3.7 nmol/l。绝经前乳腺癌风险随血浆肠内酯浓度升高而降低。与血浆肠内酯最低四分位数组相比，第三和第四四分位数组女性的调整优势比（95%置信区间）分别为0.42（0.20 - 0.90）和0.38（0.17 - 0.85）（趋势P值为0.007）。血浆染料木黄酮浓度与绝经前乳腺癌风险之间无显著关联。
通过使用植物雌激素摄入量的生物标志物，我们证实了肠内酯与绝经前乳腺癌风险之间存在如膳食摄入量估计所发现的强烈负相关关系。这一结果支持了哺乳动物木脂素在西方人群绝经前女性预防乳腺癌中的潜在作用。
