雌激素对实验性自身免疫性脑脊髓炎的保护作用可调节微生物群和黏膜相关调节细胞。
Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.
作者信息
Benedek Gil, Zhang Jun, Nguyen Ha, Kent Gail, Seifert Hilary A, Davin Sean, Stauffer Patrick, Vandenbark Arthur A, Karstens Lisa, Asquith Mark, Offner Halina
机构信息
Neuroimmunology Research, VA Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd, Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
出版信息
J Neuroimmunol. 2017 Sep 15;310:51-59. doi: 10.1016/j.jneuroim.2017.06.007. Epub 2017 Jun 21.
Abstract
Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.
摘要
性激素对多发性硬化症具有免疫调节作用。在本研究中，我们评估了雌激素处理或假手术处理的雌性小鼠在诱导自身免疫性脑脊髓炎（EAE）前后肠道微生物群的组成以及黏膜相关调节细胞。用孕期水平的雌激素进行处理会引起肠道微生物群组成和多样性的变化。此外，雌激素可预防EAE相关的肠道微生物群变化，并可能促进与免疫调节相关细菌的富集。我们的结果表明性激素与肠道微生物群之间可能存在相互作用，这可能促进神经保护。
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