雌激素保护的实验性自身免疫性脑脊髓炎小鼠中M2巨噬细胞/小胶质细胞与调节性B细胞之间的新型反馈回路。
Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.
作者信息
Benedek Gil, Zhang Jun, Nguyen Ha, Kent Gail, Seifert Hilary, Vandenbark Arthur A, Offner Halina
机构信息
Neuroimmunology Research, VA Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
Neuroimmunology Research, VA Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
出版信息
J Neuroimmunol. 2017 Apr 15;305:59-67. doi: 10.1016/j.jneuroim.2016.12.018. Epub 2017 Jan 28.
Immunoregulatory sex hormones, including estrogen and estriol, may prevent relapses in multiple sclerosis during pregnancy. Our previous studies have demonstrated that regulatory B cells are crucial for estrogen-mediated protection against experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of alternatively activated (M2) macrophages/microglia that results in an increased frequency of regulatory B cells in the spinal cord of estrogen treated mice with EAE. We further demonstrate that cultured M2-polarized microglia promote the induction of regulatory B cells. Our study suggests that estrogen neuroprotection induces a regulatory feedback loop between M2 macrophages/microglia and regulatory B cells.
免疫调节性激素，包括雌激素和雌三醇，可能会预防孕期多发性硬化症的复发。我们之前的研究表明，调节性B细胞对于雌激素介导的实验性自身免疫性脑脊髓炎（EAE）保护作用至关重要。在此，我们证明了雌激素依赖性诱导的替代性活化（M2）巨噬细胞/小胶质细胞，这导致在接受雌激素治疗的EAE小鼠脊髓中调节性B细胞的频率增加。我们进一步证明，培养的M2极化小胶质细胞可促进调节性B细胞的诱导。我们的研究表明，雌激素神经保护作用诱导了M2巨噬细胞/小胶质细胞与调节性B细胞之间的调节反馈回路。
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