Structural and functional analyses of the spliceosome requires a multi-disciplinary approach.
作者信息
Ohi Melanie D
机构信息
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, United States; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, United States.
出版信息
Methods. 2017 Aug 1;125:1-2. doi: 10.1016/j.ymeth.2017.07.022.
Abstract
摘要
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Structural and functional analyses of the spliceosome requires a multi-disciplinary approach.剪接体的结构和功能分析需要采用多学科方法。
Methods. 2017 Aug 1;125:1-2. doi: 10.1016/j.ymeth.2017.07.022.
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Studying structure and function of spliceosomal helicases.研究剪接体解旋酶的结构与功能。
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Reversibly constraining spliceosome-substrate complexes by engineering disulfide crosslinks.通过工程化二硫键交联可逆地约束剪接体-底物复合物。
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Structure determination of group II introns.II类内含子的结构测定
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Cryo-EM: beyond the microscope.冷冻电镜：超越显微镜。
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The effects of structure on pre-mRNA processing and stability.结构对前体信使核糖核酸加工及稳定性的影响。
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Methodologies for studying the spliceosome's RNA dynamics with single-molecule FRET.利用单分子荧光共振能量转移研究剪接体RNA动态变化的方法。
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