O'Callaghan C, Milner A D, Swarbrick A
Lancet. 1986;2(8521-22):1424-5. doi: 10.1016/s0140-6736(86)92735-2.
In 13 infants with a history of wheezing, airways resistance and specific conductance worsened after administration of nebulised salbutamol (0.5 ml sabutamol respirator solution in 1.5 ml normal saline). This paradoxical bronchoconstriction was greatest at 5 min and lasted for up to 15 min. The nebulised solution was found to be acidic and hypo-osmolar, both of which properties have been linked to bronchoconstriction in asthmatic subjects, but even with an initially iso-osmolar solution osmolality increased with time of nebulisation because of evaporation.
在13名有喘息病史的婴儿中，雾化吸入沙丁胺醇（0.5毫升沙丁胺醇雾化液加1.5毫升生理盐水）后气道阻力和比传导率恶化。这种矛盾性支气管收缩在5分钟时最为明显，持续长达15分钟。发现雾化液呈酸性且低渗，这两种特性都与哮喘患者的支气管收缩有关，但即使最初是等渗溶液，由于蒸发，随着雾化时间的延长渗透压也会升高。
