Abdul Rehman Saad, Khurshid Zohaib, Hussain Niazi Fayez, Naseem Mustafa, Al Waddani Hamed, Sahibzada Haafsa Arshad, Sannam Khan Rabia
Department of Orthodontics, College of Dentistry, Karachi Medical and Dental College, Karachi 74700, Pakistan.
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Proteomes. 2017 Aug 7;5(3):21. doi: 10.3390/proteomes5030021.
Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below.
人全口唾液（WMS）由唾液腺分泌，即腮腺、颌下腺/舌下腺以及口腔中的其他小腺体。它以一种有系统的方式分泌，并且含有用于早期检测传染病和器官相关疾病的信息性蛋白质和肽。在过去十年中，人全口唾液作为一种液体活检手段，通过肌红蛋白（MYO）、心肌肌钙蛋白I（cTnI）、肌酸磷酸激酶同工酶MB（CK-MB）、髓过氧化物酶（MPO）、脑钠肽（NT-proBNP）、外泌体微小RNA、C反应蛋白（CRP）、基质金属蛋白酶-8（MMP-8）、MMP-9和MMP-8组织抑制剂（TIMP-1）、白三烯B4来检测心血管疾病（CVD）的作用已得到充分报道，以下将在文献中对其进行全面综述。
