网络分析确定了六种与肥胖相关疾病中与肥胖相关的常见基因。
Network analysis identifies common genes associated with obesity in six obesity-related diseases.
作者信息
Su Li-Ning, Wang Yan-Bing, Wnag Chun-Guang, Wei Hui-Ping
机构信息
Department of Biology, Hebei North University, Zhangjiakou 075029, China.
Department of Public Sports, Hebei North University, Zhangjiakou 075029, China.
出版信息
J Zhejiang Univ Sci B. 2017;18(8):727-732. doi: 10.1631/jzus.B1600454.
Abstract
Obesity has been reported to be associated with many diseases. However, common obesity-induced biological processes have not been evaluated across these diseases. We identified genes associated with obesity and obesity-related diseases, and used them to construct protein‒protein interaction networks. We also analyzed gene ontology (GO) in those genes overlapping between obesity and disease. Our work identifies gene modules common to obesity and obesity-related diseases, which can provide a basis for understanding the process of how obesity induces disease.
摘要
据报道，肥胖与许多疾病有关。然而，尚未在这些疾病中评估常见的肥胖诱导生物学过程。我们鉴定了与肥胖及肥胖相关疾病相关的基因，并利用它们构建蛋白质-蛋白质相互作用网络。我们还分析了肥胖与疾病之间重叠的那些基因中的基因本体（GO）。我们的工作确定了肥胖与肥胖相关疾病共有的基因模块，这可为理解肥胖如何诱发疾病的过程提供依据。
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