Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-210 Gdansk, Poland.
First Department of Cardiology, Medical University of Gdansk, 80-210 Gdansk, Poland.
Genes (Basel). 2023 Feb 26;14(3):594. doi: 10.3390/genes14030594.
Psoriasis comorbidities may emerge from pleiotropic mechanisms, including common proinflammatory pathways, cellular mediators or genetic predisposition. Obesity is considered to be an independent risk factor of psoriasis, which may influence the severity of the disease and its early onset, decrease patients' quality of life, alter response to psoriasis therapies and affect morbidity by reduced life expectancy due to cardiovascular events. Although novel approaches, including genetic techniques, have provided a wide range of new research, there are still scarce studies elaborating on the common genetic background of psoriasis and obesity. The aim of this study was to present and evaluate a possible common genetic background of psoriasis and concomitant increased body mass based on the review of the available literature.
银屑病的合并症可能源于多种机制，包括共同的促炎途径、细胞介质或遗传易感性。肥胖被认为是银屑病的一个独立危险因素，它可能影响疾病的严重程度和早期发病，降低患者的生活质量，改变对银屑病治疗的反应，并因心血管事件导致预期寿命缩短而增加发病率。尽管包括遗传技术在内的新方法提供了广泛的新研究，但仍缺乏详细阐述银屑病和肥胖症共同遗传背景的研究。本研究旨在通过对现有文献的回顾，提出并评估银屑病和伴发的体重增加可能存在的共同遗传背景。
