羟甲叔丁肾上腺素与阿替洛尔对哮喘患者通气及血流动力学影响的比较研究。
A comparative study on the ventilatory and haemodynamic effects of xamoterol and atenolol in asthmatic patients.
作者信息
Lammers J W, Müller M E, Folgering H T, van Herwaarden C L
出版信息
Br J Clin Pharmacol. 1986 Nov;22(5):595-602. doi: 10.1111/j.1365-2125.1986.tb02940.x.
Abstract
The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which changes are consistent with the partial beta 1-adrenoceptor agonist activity of this drug. Atenolol induced a significant decrease in FEV1 and the forced vital capacity (FVC); there was a non-significant change in FEV1 and FVC after xamoterol. There was no significant difference between the effects of atenolol and xamoterol of FEV1 and FVC. Bronchospasm induced by atenolol 50 mg and xamoterol 200 mg was completely reversed by inhalation of the beta 2-adrenoceptor agonist terbutaline to a cumulative dose of 4.0 mg.
摘要
在11例哮喘患者中研究了单次口服50毫克阿替洛尔和200毫克扎莫特罗（一种最近研发的β1肾上腺素能受体部分激动剂）对肺功能、心率和血压的影响。扎莫特罗导致心率和收缩压显著升高，这些变化与该药物的β1肾上腺素能受体部分激动剂活性一致。阿替洛尔使第一秒用力呼气量（FEV1）和用力肺活量（FVC）显著降低；扎莫特罗给药后FEV1和FVC有不显著变化。阿替洛尔和扎莫特罗对FEV1和FVC的影响之间无显著差异。吸入累计剂量达4.0毫克的β2肾上腺素能受体激动剂特布他林可完全逆转50毫克阿替洛尔和200毫克扎莫特罗诱发的支气管痉挛。
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